Background: Hydatidosis is one of the cosmopolitan parasitic zoonoses caused by the larval stage of Echinococcus granulosus. Diagnosis of hydatidosis is still an unresolved problem. Serological tests using crude antigens for diagnosis of E. granulosus are sensi-tive, however their specificity are not satisfactory. Therefore, WHO recommended spe-cific serological methods using specific antigens,...

conclusions this study demonstrated the detection of hcv-specific ifn-γ responses in hcv antibody and rna negative individuals, with a tendency for hcv-specific ifn-γ responses to be associated with hcv exposure. the potential role of hcv-specific ifn-γ responses in those who remained hcv rna negative is of value for the development of novel hcv therapeutics. objectives in a cohort of hcv antib...

Myasthenia Gravis (MG) is a neuromuscular junction disorder caused by pathogenic autoantibodies to some parts of the post-synaptic muscle endplates. About 85% of generalized MG patients have autoantibodies against post-synaptic acetyl-choline receptors (AChR). From the 10-15% of the remaining patients, 45-50% are positive for Muscle Specific Tyrosine Kinase-Antibody (MuSK-Ab). It is believed th...

aim : this study was designed to evaluate the frequency of antibody against these viruses in individuals attending the endoscopy ward of taleghani hospital tehran, iran. background : blood-borne viruses such as hepatitis b and hepatitis c virus and htlv-1 virus are among the world’s public health problems. hepatitis viruses cause liver problems and htlv-1 infection can lead to adult t-cell lymp...

We measured anti-SARS-CoV-2 antibody responses before and after CoronaVac (inactivated) vaccination in a case–control study performed CoronaVac-immunized individuals participating longitudinal prospective of adults Manaus (DETECTCoV-19). Antibody were by standard serological immunoassays. Peak anti-S-RBD neutralizing RBD-ACE2 blocking two doses vaccine similar breakthrough cases (n = 9) matched...

The testing of anti-neutrophil cytoplasmic antibodies (ANCA) takes an important place in the diagnostic workup to ANCA-associated vasculitis (AAV). Nowadays, it is recommended screen for presence PR3 and MPO specific first using immunoassay, without need ANCA measurement by indirect immunofluorescence (IIF). A literature search was performed assess test value IIF PR3- MPO-antibody immunoassay d...

Pre-clinical and clinical studies of therapeutic antibodies require highly specific reagents to examine their immune responses, bio-distributions, immunogenicity, and pharmacodynamics in patients. Selective antigen-mimicking anti-idiotype antibody facilitates the assessment of therapeutic antibody in the detection, quantitation and characterization of antibody immune responses. Using mouse spec...

Background and Aims: Influenza is an acute respiratory illness that is caused by a virus belonging to Orthomyxoviridae family. This virus spreads rapidly every year in cold season and leads to morbidities and mortalities especially in adults and children, which causes billions of dollars of economic losses. Accordingly, development of a rapid, sensitive and inexpensive laboratory diagnosis base...

Therapeutic antibodies blocking PD-1-/PD-L1 interaction have achieved remarkable clinical success in cancer. In addition to a target molecule, some isotypes of can activate complement, NK cells or phagocytes, resulting death the cell expressing antibody's target. Human anti-PD-1 therapeutics use antibody designed minimize such antibody-dependent lysis. contrast, reagents used mice are derived f...