Abstract Brassicaceae familyare traditional, medicinal and nutritional value plants. family produced valuable components to provide different types of beneficial effects for humans animals such as anti-oxidant, antimicrobial, anticancer, anti-scurvy, anti-inflammatory, anti-hyperglycemic, anti-tumor, anti-diabetes, anti-stomach diseases, anti-cardio, This review mainly focus observe response in...

BACKGROUND AND PURPOSE Despite the potent tumoricidal activity of the synthetic dsRNA in culture, its in vivo anti-tumor activity has proven to be limited. We sought to devise and validate a new strategy to improve the in vivo anti-tumor activity by integrating localized irradiation into dsRNA therapy. MATERIALS AND METHODS Using a mouse lung cancer model and a mouse melanoma model in immuno-...

CD39 is an extracellular ectonucleotidase highly expressed in the tumor microenvironment (TME) that, sequentially with CD73, contributes to production of adenosine (Ado), via hydrolysis triphosphate (ATP). IPH5201 a blocking anti-CD39 monoclonal antibody (mAb) that may promote antitumor immunity by accumulating immunostimulatory ATP released necrotic cells and reducing immunosuppressive Ado lev...

This review focuses on advances and strategies in the use of iron chelators as anti-tumor therapies. Although the development of iron chelators for human disease has focused primarily on their use in the treatment of secondary iron overload, chelators may also be useful anti-tumor agents. They can deplete iron or cause oxidative stress in the tumor due to redox perturbations in its environment....

Immunotherapies targeting the immune checkpoint receptors have shown great promise for a subset of cancer patients. However, robust and safe combination therapies are still needed to increase the benefit of cancer immunotherapy and bring it to broader patient populations. We have recently shown that E7046, a specific EP4 antagonist, possesses significant anti-tumor growth activity in multiple p...

The present study is a case report of patient with diagnosis renal cell carcinoma poor prospects, in whom long-term tumor control at the level deep cytoreduction was achieved through aggressive multidisciplinary management using surgery, stereotactic radiotherapy, and sequential systemic therapy immunotherapy based on checkpoint inhibitor anti-PDL1 activity combined anti-angiogenic treatment, b...