نتایج جستجو برای: apc
تعداد نتایج: 12498 فیلتر نتایج به سال:
Germ-line mutations in the tumor suppressor gene APC are associated with hereditary familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal tumors. We now report that methylation in the promoter region of this gene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastrointestinal tract. The APC promoter is hypermet...
Mutations in the adenomatous polyposis coli (Apc) tumor suppressor gene represent the primary genetic defect in colon carcinogenesis. Apc+/- mouse models exhibit pre-invasive small intestinal adenomas. Cell culture models exhibiting Apc defects in the colon and quantifiable cancer risk provide a novel clinically relevant approach. The tumor-derived Apc-/- colonic epithelial cell line 1638N COL-...
A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group ...
سرطان روده بزرگ سومین سرطان شایع در جهان است. با توجه به افزایش بروز سرطان استفاده از مولکول های جدید شیمی درمانی مورد نیاز می باشد. بسیاری از مطالعات و تحقیقات نشان داده است که سرطان روده می تواند از طریق محصولات دریایی طبیعی که دارای مقادیر بسیاری از مواد فعال بیولوژیکی با ساختارهای شیمیایی و فعالیت های دارویی جدید هستند درمان شود. هدف از این مطالعه بررسی اثرات عصاره هیدروالکلی جلبک Sargassum...
Background and Objective: Deep vein thrombosis (DVT) is one of the most common forms of venous thromboembolism (VTE). Deficiency in natural anticoagulant proteins is considered to be the major cause of thrombosis. In the present study, we investigated the incidence of defects in protein S, protein C, antithrombin and resistance to activated protein C (APC-R) in patients with DVT referred to the...
The Amirkabir petrochemical complex (APC) is located in the south of Iran, on the northern coastline of the Persian Gulf. It has five different units which generate various waste estimated at 3115.98 ton/year. The objective of this study was to focus on the management of the processing wastes for minimizing the adverse environmental impacts. In order to properly manage and control waste generat...
هدف این مقاله، بررسی امکان مصرف PCC و اثر وزن پوشش آنها در پوشش‌دهی کاغذ است. در این مطالعه از دو نوع کاغذ پایه کارخانه چوب و کاغذ مازندران (NS و APC)، استفاده شد. دو ترکیب پوشش‌دهی با مواد جامد 25 درصد، شامل پرکننده PCC (100 قسمت)، متصل‌کننده PVA (14 قسمت) و پراکنده ساز (1 قسمت) بود. ترکیب اول جهت افزایش ماتی دارای PCC B102 و ترکیب دوم به منظور بهبود درجه روشنی حاوی PCC 9020 بود. دو میله پوشش...
Background/Aim. Direct oral anticoagulants (DOACs) administration significantly interferes with coagulation as-says. The aim of the study was to evaluate effect DOACs and DOAC-Remove? on assays during thrombophilia testing. Methods. carried out from January 2019 end June 2020. It included 30 DOAC-treated patients, 14 females 16 males aged 23 63 (median age 47.6 years), tested for due venous thr...
Changes in mitochondrial bioenergetics have been proposed to be critical for triggering and effecting anesthetic-induced preconditioning (APC) against cardiac ischemia and reperfusion injury. The objective of this study was to analyze changes in mitochondrial protein levels and link those changes to potential functional changes. A (18)O-labeling method was applied for relative comparison of car...
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