Microbiological control is of crucial importance in the pharmaceutical industry regarding the possible bacterial contamination of the environment, water, raw materials and finished products. Molecular identification of bacterial contaminants based on DNA sequencing of the hypervariable 16SrRNA gene has been introduced recently. The aim of this study is to investigate the suitability of gene seq...

A number of nanotechnology-enabled drug delivery platforms are in varying stages of drug development. While, physiologically-based pharmacokinetic (PBPK) modelling has become a well-established tool for conventional medicines from preclinical to post-licensing environments, its application for nanomedicines is in its infancy. Part of the reason for this is that the fundamental mechanisms that u...

For a long time, chromatographic techniques and techniques related to them have stimulated the development of new procedures in the field of pharmaceutical analysis. The newly developed methods, characterized by improved metrological parameters, allow for more accurate testing of, among others, the composition of raw materials, intermediates and final products. The chromatographic techniques al...

The emerging location-detection devices together with ubiquitous connectivity have enabled a large variety of locationbased services (LBS). Location-based services are becoming popular for mobile users. The mobile users’ location plays a key role to provide the service from one side, but it can be considered as a dimension of their privacy and so necessary to keep it anonymous to the other part...

Research is essential in that it is required to provide the scientific evidence that helps ensure patients receive the appropriate treatment. Evidence based medicine is now recognised as essential for all patients. Historically, both pregnant women and paediatric patients have been neglected by researchers. Clinical trials are more challenging in both of these patient groups. Additionally, the ...

Background: Clinical research is a specific phase of the production process in the pharmaceutical industry in which companies test candidate drugs on patients in order to collect clinical evidence about safety and effectiveness.Objective: This paper is an operational research which aimed to support the hypothesis that pharmaceutical clinical research is l...

Control of elemental impurities in pharmaceutical materials is currently undergoing a transition from control based on concentrations in components of drug products to control based on permitted daily exposures in drug products. Within the pharmaceutical community, there is uncertainty regarding the impact of these changes on manufactures of drug products. This uncertainty is fueled in part by ...

In today's competitive world, there are several strategies to deal with the fast changing environment, among which New product development (NPD) is a common strategy. However, almost half of the resources that companies devote to NPD are spent on products that may fail. This issue is particularly highlighted in the pharmaceutical industry mainly because of a long development-time, low success r...