I report how some adulterants affect results for drugs of abuse in urine as measured by Roche RIA, Syva emit d.a.u., and Abbott TDx fpia (fluorescence polarization immunoassay) for the following drugs: amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates, and phencyclidine (PCP). Sodium chloride interfered negatively with all of these drugs when assayed by emit and caused...

OBJECTIVE Benzodiazepines are frequently screened drugs in emergency toxicology, drugs of abuse testing, and in forensic cases. As the variations of benzodiazepines concentrations in biological samples during bleeding, postmortem changes, and redistribution could be biasing forensic medicine examinations, hence selecting a suitable sample and a validated accurate method is essential for the qua...

Jill: A handful of past studies have suggested a link between dementia and benzodiazepine use. Because it is not possible to do randomized controlled trials to evaluate this, researchers are working to answer this important public health question by accumulating evidence in many different populations and settings to assess whether the relationship is causative or merely an association with othe...

The advantages of the benzodiazpines as oral premedicants are: clear anxiolytic and sedative effect; less clear amnesic action which may prevent the recall of the time spent lying on an uncomfortable theatre trolley, but not necessarily recall of the journey to the operating theatre, or induction of anaesthesia; convenient route of administration; long duration of action of 5-8 h which simplifi...

There are now more recently published studies that also support this view and which add to the reasons I gave in my previous column as to why the presence of chronic pain and the prescription of opioids are usually contraindications for prescribing benzodiazepines. The pharmacy benefit company Express Scripts examined 6.8 million patients who filled at least one prescription for an opioid from ...

The cycloaddition reaction of diphenylnitrilimine on the 1,5-benzodiazepines has been studied. New molecules of triazolobenzodiazepines type have been isolated and characterized.