The objective of this research topic “Inorganic Biomaterials” within the scope of the article series “Bioengineering and Biotechnology” featured by the open access journal “Frontiers” was to present a comprehensive introduction to the field of inorganic bioactive biomaterials being considered for the replacement of hard tissues, in particular, bone tissue and related topics in bone tissue engin...

Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid-implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorgan...

PURPOSE This study evaluates the temporal sequence and growth factor release from platelet-rich plasma (PRP) combined with different bone substitutes (BS), to identify an optimal substrate for extended growth factor retention. MATERIALS AND METHODS PRP was clotted with bovine thrombin or thrombin receptor activator peptide-6 (TRAP). In addition, PRP was clotted using Allogro (Ceramed, Lakewoo...

Abstract Bone implant failure due to aseptic loosening and biofilm infections is an increasing healthcare problem. Implants may be coated with nanoparticles avoid bacterial colonization promote osseointegration. However, these nanocoatings often require long, expensive, complex manufacturing routes limited clinical translation potential. Here, a multifunctional nanoparticle coating consisting o...

This work focuses on designing bilayered constructs by combining electrospun poly-DL-Lactide (PDLLA) fibers and Bioglass®-derived scaffolds for development of osteochondral tissue replacement materials. Electrospinning was carried out using a solution of 5 wt/v% PDLLA in dimethyl carbonate. The PDLLA layer thickness increased from 2 to 150 µm with varying electrospinning time. Bioactivity studi...