Over the years many synthetic routes have been reported for the preparation of benzofurans [1,4,5]. Iodocyclization of functionalized alkynes is one of the most important and efficient synthetic methodologies for the synthesis of important heterocyclic compounds, including benzofurans [6,7]. Due to our continuous interest in the synthesis and biological evaluation of important heterocycles, [8-...

Ongoing efforts to unravel the origins of the cholesterol 5,6-secosterols (1a and 1b) in biological systems have revealed that the two known chemical routes to these oxysterols, ozonolysis of cholesterol (3) and Hock-cleavage of 5-alpha-hydroperoxycholesterol (4a), are distinguishable based upon the ratio of the hydrazone derivatives (2a and 2b) formed in each case and this ratio offers an insi...

Inference and prediction of routes have become interest over the past decade owing to a dramatic increase in package delivery ride-sharing services. Given underlying combinatorial structure incorporation probabilities, route involves techniques from both formal methods machine learning. One promising approach for predicting uses decision diagrams that are augmented with probability values. Howe...

The single vehicle routing problem with multiple routes is a variant of the vehicle routing problem where the vehicle can be dispatched to several routes during its workday to serve a number of customers. In this paper we propose a goal programming model for multi-objective single vehicle routing problem with time windows and multiple routes. To solve the model, we present a heuristic method wh...

Not satisfied with biology's vast catalyst repertoire, I want to create new enzyme catalysts and expand the chemistry of life. We use most powerful biological design process, evolution, optimize existing enzymes invent ones, thereby circumventing our profound ignorance how sequence encodes function. Chemistry encoded in DNA optimized by evolution enables efficient, sustainable routes important ...