Background: Children of parents with bipolar disorder appear to have an increased risk of early-onset Bipolar Disorder (BP), mood disorders and other psychiatric disorders. Objectives: The aim of this study was to compare the mental health of school-age children of parents, with/without bipolar disorder. Materials and Methods: This case-control study included one hundred children aged six to tw...

OBJECTIVE Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis. METHOD The authors selected families with bipolar disorder from their previous bi...

We found evidence previously of familial aggregation of psychotic symptoms in 65 bipolar disorder pedigrees. This finding, together with prior evidence from clinical, family, neurobiological, and linkage studies, suggested that psychotic bipolar disorder may delineate a valid subtype. We sought to replicate this finding in 69 new bipolar disorder pedigrees. The presence of psychotic symptoms, d...

OBJECTIVE To review systematically the main clinical trials on the pharmacological treatment of bipolar disorder and to make a critical analysis of their methodological aspects. METHOD A search in Medline, ISI and PsycINFO databases was conducted, using the following search terms: "bipolar", "randomized", "placebo" e "controlled". Randomized, double-blind, placebo-controlled clinical trials o...

BACKGROUND The influence of psychosocial stress on the course of bipolar disorder has been increasingly recognized. The authors tested hypotheses about both stress and early adversity "sensitization" on the course of bipolar disorder over a one-year period. METHODS The participants were 58 adults (29 male and 29 female) with a diagnosis of bipolar I disorder. They were evaluated every three m...

objective: to describe a home care service developed in roozbeh hospital for patients with bipolar disorder and schizophrenia and report baseline and 6-month follow-up data. method: roozbeh home care program consists of home visits by multidisciplinary home care teams, including general practitioners, nurses, and social workers who are supervised by psychiatrists. home visits are scheduled as b...

objectives: to study the prevalence and demographic characteristics of neurological soft signs (nss) among the patients with bipolar mood disorder-i (bid). method: in a cross- sectional descriptive-analytic study we studied 20 patients with bid with bid with 20 healthy individuals. we used dsm-iv and young mania rating scale (mrs) for diagnosing and rating the patients with bid, neurological ev...

aim and background: the present study aimed to investigate the symptom severity and quality of life in patients suffering from bipolar disorder. methods and materials: this longitudinal and prospective study was done on 20 patients with bipolar type i disorder who were hospitalized in noor hospital of isfahan, iran. patients were evaluated before hospitalization, at the time of discharge, 3 and...