Nanoscopic particles self-assembled from amphiphilic block copolymers have been developed over the past years for the preparation of various drug delivery systems. The biodegradable carriers made of polyethylene glycol (PEG)-polyester diblock copolymers emerged as the most adequate devices due to their prolonged circulation half-life in blood, their ability to bypass natural barriers, their red...

The present work concerns on the investigation of the role of polyethylene glycols (PEGs) as masking agent for amelioration of extraction-separation of La(III), Eu(III) and Er(III) ions by the acidic extractant bis(2-ethylhexyl)phosphoric acid (DEHPA). The studied solvent extraction system is based on the combination of chelating effect of DEHPA in the organic phase on the one hand, and the bin...

Cyanylation of myosin with 6-thiol’4Clcyanato-9-/3-o-ribofuranosylpurine shows a biphasic effect. During the incorporation of the first 4 mol of cyanide the Mg”+-dependent ATPase activity increases approximately &fold, the Ca*+ activity rises only slightly, and the K+(EDTA) activity falls to approximately 5% of its original value. These enzyme preparations can still be inactivated by N-ethylmal...

We have shown [l] that the intensity of band 4 (mol. wt 3 1 000, nomenclature from [2]) of oligomycin-sensitive ATPase from beef heart mitochondria increases in the presence of thiol reagent, 2-mercaptopropionylglycine. Here we show that the intensity of this band (which is lacking in oligomycin-insensitive ATPase [3]) decreases in the presence of 0.2 MM of the uncoupler carbonylcyanide-p-trifl...

An easy method was developed for the efficient preparation of diversely new 5,5-disubstituted N(3),N'(3)-linkaged bis-hydantoins. At first, using the same methods, some ketones and terephthalaldehyde were converted to several hydantoins and a new bis-hydantoin , respectively. Then 1,6-dibromohexane, as a mild reagent, was employed for the alkylation and incorporation of synthesized substrates t...

Numerous investigations have shown that 70-kDa heat shock protein (Hsp70) homologs interact tightly with hydrophobic proteins and functionally assist proteins in membranous organelles and environments. One such protein is the Chlamydia trachomatis Hsp70 that is associated with isolated outer membrane complexes of infectious elementary bodies (EB). Previous observations have indicated that chlam...

Objective: The objectives of the present work were to carry out thiol-modification (i.e., thiolation) fenugreek polysaccharide (FP) and assess synthesized thiolated product (TFP) as a mucoadhesive excipient in designing formulations (metronidazole gels metronidazole buccal discs). Methods: Extracted CG was thiol-modified via an esterification reaction by utilizing thioglycolic acid with acidic ...

A range of mitochondria-targeted probe molecules that comprise a lipophilic cation covalently attached to an active moiety have been developed. The lipophilic cation causes the accumulation of these molecules into mitochondria, driven by the mitochondrial membrane potential. To date, we have targeted antioxidants, spin traps, thiol reagents and DNA-alkylating compounds to mitochondria. The sele...

Cyanylation of myosin with 6-thiol’4Clcyanato-9-/3-o-ribofuranosylpurine shows a biphasic effect. During the incorporation of the first 4 mol of cyanide the Mg”+-dependent ATPase activity increases approximately &fold, the Ca*+ activity rises only slightly, and the K+(EDTA) activity falls to approximately 5% of its original value. These enzyme preparations can still be inactivated by N-ethylmal...

The author synthesized a Green reagent N, N1-bis (4-dimethyl amino benzyl) ethylene diamine for the analysis of heavy metals namely Fe, Cd, Cr, Cu and Co by FAAS using Amberlite-XAD-16 in various environmental samples. The results shows good recovery compared with the results obtained with Cytosine. Effects of pH, reagent concentration, flowrate, volume of sample etc were studied.