Low-dose total-body irradiation, 150 rad given in 10 fractions over 5 weeks, is a useful treatment modality for favorable-prognosis lymphomas. Little is known, however, about the effects of this regimen on normal bone marrow. Six healthy beagle dogs and 5 dogs of various breeds with lymphoma were treated with total-body irradiation. Three of the 5 lymphomatous dogs achieved remissions of limite...

OBJECT Accumulation of protoporphyrin IX (PPIX) in malignant gliomas is induced by 5-aminolevulinic acid (5-ALA). Because PPIX is a potent photosensitizer, the authors sought to discover whether its accumulation might be exploited for use in photoirradiation therapy of experimental brain tumors, without injuring normal or edematous brain. METHODS Thirty rats underwent craniotomy and were rand...

Irradiation of the mouse testes was carried out using internally distributed tritium from injected tritiated thymidine and tritiated water and also using external whole body irradiation with 200 kVp X-rays. The inability of intermediate spermatogonia to divide twice and produce resting primary spermatocytes was used as a criterion of biological damage and the following conclusions were reached:...

In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing radiation. We have recently shown that genome-wide expression analysis of the peripheral blood (PB) can generate gene expression profiles that can predict radiation exposure ...

Introduction: Total Skin Electron Therapy (TSET) and Total Body Irradiation (TBI) are kinds of treatment which use electron and photon beams to treat special types of cancers. The aim of these techniques are to deliver uniform dose to the entire skin while minimizing delivered dose to organs at risk. To check the homogeneity of dose delivery in TBI and TSET, using a humanoid ph...

Caffeine is an alkaloid (purine derivative) that contains flavonoids ,where as aspirin, natural component of mammalian tissue (acetylsalicylic acid) is one of the most commonly used non steroidal anti-inflammatory, and it is a necessary factor in the utilization of long-chain fatty acids to produce energy. Furthermore, it has been shown to protect cells from peroxidative stress. The objective o...

Whereas increasing concerns about radiation exposure to nuclear disasters or side effects of anticancer radiotherapy, relatively little research for radiation damages or remedy has been done. The purpose of this study was to establish level of LD70/30 (a lethal dose for 70% of mice within 30 days) by total-body γ irradiation (TBI) in a mouse model. For this purpose, at first, 8-week-old male IC...

background:  hydrogen has been demonstrated can selectively reduce the hydroxyl, which is the main cause of ionizing radiation-induced damage. amifostine (am) is the only radioprotective drug approved by the u.s. food and drug administration for use in radiotherapy. the purpose of the present study was to investigate the combined radio-protective effect of hydrogen rich water (hrw) and am. mate...

We examined the radioprotective and mitigative effects of gamma-tocopherol-N,N-dimethylglycine ester (GTDMG), a novel water-soluble gamma-tocopherol derivative, against X-irradiation-induced bone marrow death in mice. Mice (C3H, 10 weeks, male) were injected intraperitoneally with GTDMG suspended in a 0.5% methyl cellulose solution before or after receiving of 7.5-Gy whole body X-irradiation. G...