background differences in causes, severities, areas of stenosis, and the association with swallowing and phonation of larynx and trachea can result into laryngotracheal stenosis (lts).this study evaluated the healing effect of bone marrow stem cells (bmscs) in experimentally induced lts dog model. methods seven dogs were enrolled. bmscs were isolated from proximal humerus and shoulder of a dog ...

background: bone marrow stromal cells (bmsc) have been successfully employed for movement deficit recovery in spinal cord injury (sci) rat models. one of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. according to our previous studies, p75 receptor, known as the death receptor, is only expressed in bmsc in...

background: bone marrow stromal stem cells (bmsc) are appropriate source of multipotent stem cells that are ideally suited for use in various cell-based therapies. it can be differentiated into neuronal-like cells under appropriate conditions. this study examined the effectiveness of co-stimulation of creatine and retinoic acid in increasing the differentiation of bmsc into gabaergic neuron-lik...

background: adipose-derived stem cells (adsc) could be an appealing alternative to bone marrow stem cells (bmsc) for engineering cell-based osteoinductive grafts. meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. therefore, we assayed and compared the melatonin effect on osteogenic differentiation of bmsc with that of adsc. methods: mesenchymal ...

generation neural stem cells from neurosphere–derived bone marrow stem cells using bioactive substance atc. bone marrow cells (bmscs) were isolated from rat. bmscs cultured by dmem/f12 medium supplemented with 10% fetal bovine serum. these cells evaluated by specific markers of bmscs such as bioactive substance atc, b27. then bmscs differentionated in to neurosphere and divided in two groups wh...

conclusions due to the high risk of non-:union: and mal-:union: in humerus shaft fracture, and because applying this simple and inexpensive technique significantly decreased these complications, injecting autologous bone marrow grafts is recommended for accelerating :union: in cases of humerus fracture. results the mean time of :union: was 8.54 ± 3.41 weeks for the individuals followed in the s...

conclusions our findings showed that the treatment of flaps with bm-msc and aam transplantations significantly promoted flap survival compared to a control group. the viability of the flap was improved by combining bm-mscs with aam matrix scaffolds. materials and methods bm-mscs and aams were transplanted into subcutaneous tissue in the flap area. on the 7th postoperative day, the surviving fla...

background: previous investigations have revealed, cimetidine, a histamine h2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. in this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine h2-receptor antagonists, was investigated. materials and methods : balb/c m...

the relationship between the way in which normal hemopoietic stem cells respond to irradiation alone or in the presence of bleomycin sulfate (blm-s) and actinomycin 0 (act-d) was investigated. single doses of blm-s at 0.3 mg/kg and act-o at 0.10 mg/kg body weight were injected intravenously 1-6 hours prior to whole body irradiation and treatment was repeated twice more with time intervals. when...