background: the purpose of this study was to find the accurate absorbed dose in the femur bone marrow during the x-ray radiography for constant mas and aec techniques. materials and methods: the dosxyznrc was used to simulate radiation doses in two human femurs during diagnostic radiography. egsnrc phantoms produced from actual ct images of human femurs were modified by adding seven micrometre ...

background: radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 gy for non-myeloablative therapies. the aim of this study was to calculate bone marrow radiation dose by using mirdose3 package program and to optimize the safe limit of activity to be administered to the thyroid cancer patients. materials and methods: in t...

A method is described for computing patient-specific absorbed dose rates to active marrow which accounts for spatial variation in bone volume fraction and marrow cellularity. A module has been added to the 3D Monte Carlo dosimetry program DPM to treat energy deposition in the components of bone spongiosa distinctly. Homogeneous voxels in regions containing bone spongiosa (as defined on CT image...

An important problem in internal dosimetry is the assessment of energy deposition by beta particles within trabecular regions of the skeleton. Recent dosimetry methods for trabecular bone are based on Monte Carlo particle transport simulations within three-dimensional (3D) images of real human bone samples. Nuclear magnetic resonance (NMR) microscopy is a 3D imaging technique of choice due to t...

Hematologic toxicity limits the radioactivity that may be administered for radiolabeled antibody therapy. This work examines approaches for obtaining biodistribution data and performing dosimetry when the administered antibody is known to bind to a cellular component of blood, bone, or marrow. Marrow dosimetry in this case is more difficult because the kinetics of antibody clearance from the bl...

Radiation dose estimates to the trabecular region of the skeleton are of primary importance due to recent advancements in nuclear medicine. Establishing methods for accurately calculating dose in these regions is difficult due to the complex microstructure of this anatomic site and the typical ranges of beta-particles in both bone and marrow tissues. At the present time, models of skeletal dosi...

Radionuclide therapy extends the usefulness of radiation from localized disease of multifocal disease by combining radionuclides with disease-seeking drugs, such as antibodies or custom-designed synthetic agents. Like conventional radiotherapy, the effectiveness of targeted radionuclides is ultimately limited by the amount of undesired radiation given to a critical, dose-limiting normal tissue,...

Dosimetric modeling of radiation transport in skeletal bone tissues using computational phantoms provides the doses internal exposure to active marrow. Computational ICRP are created for reference people with anatomical and physiological characteristics typical an average individual. The calculated such will correspond certain population-average values. Individual variability introduce a stocha...