Purpose: To determine, in Sprague Dawley rats, the toxicity profile of the methanol extract of Mentha spicata, a plant used in folklore medicine for the treatment of various forms of pain. Methods: The plant extract, at concentrations ranging from 100 0.07 mg/ml, was used to determine the median lethal concentration (LC50) based on brine shrimp lethality assay. Artificial sea water served as co...

Artemia franciscana nauplii is a source of nutrients and pathogen vectors due to the non-selective nature filter feeder. Prevention pathogens done by adding iodine disinfectant suppress emergence bacteria. One way find out if substance toxic testing toxicity lethal concentration (LC50) on A. nauplii. The aim this study was evaluate effect determine in 50% (LC50). Brine Shrimp Lethality Test (BS...

A follow-up chemical investigation to methanol extract of Conyza dioscoridis (Family Asteraceae) led to the isolation of seven compounds (1-7). The isolated compounds identified as 2-(3,4-dihydroxyphenyl)ethyl-2-O-[6-deoxy-α-Lmannopyranosyl-4-(3,4-dihydroxyphenyl)-2-propenoate]-β-D-glucopyranoside (1), rutin (2), isoquercetin (3), E-caffeic acid (4), gallic acid (5), quercetin (6), β-Sitosterol...

Acacia mearnsii De Wild. (Fabaceae) is a medicinal plant used in the treatment of microbial infections in South Africa without scientific validation of its bioactivity and toxicity. The antimicrobial activity of the crude acetone extract was evaluated by both agar diffusion and macrobroth dilution methods while its cytotoxicity effect was assessed with brine shrimp lethality assay. The study sh...

Indonesia, especially in the Riau Islands has abundant marine biological natural resources. So that it can be used as basic ingredient of a search for medicinal or materials. One them is caulerpa racemosa sea grape type from green algae group which contains variety secondary metabolites with bioactive compounds are cytotoxic to kill cancer cells. This study aims determine activity ethanol extra...