background and objectives: phlomis olivieri benth. (lamiaceae) is a medicinal plant widely distributed in iran. in the present study, we have investigated the phytochemical constituents, antioxidant activity and general toxicity potential of the aerial parts of this species. methods: silica gel (normal and reversed phases) and sephadex lh-20 column chromatographies were used for isolation of co...

Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn. (MEMA) leaves in rats and brine shrimp, respectively. Antidiarrheal effec...

Objective: To investigate the antifungal, haemolytic and cytotoxic activity of methanol and methanol: chloroform extracts of the marine Mollusks (10 Gastropods, 5 Bivalves, 2 Cephalopods) and 1 Echinoderm. Methods: Crude methanol and methanol: chloroform extracts of the marine Mollusks (10 Gastropods, 5 Bivalves, 2 Cephalopods) and 1 Echinoderm were tested for antifungal activity using disc dif...

Medicinal plants constitute an important component of flora and are widely distributed in India. The pharmacological evaluation of substances from plants is an established method for the identification of lead compounds which can leads to the development of novel and safe medicinal agents. Based on the ethnopharmacological literature, several species of medicinal plants used in traditional medi...

BACKGROUND The brine shrimp lethality assay is considered a useful tool for preliminary assessment of toxicity. It has also been suggested for screening pharmacological activities in plant extracts. However, we think that it is necessary to evaluate the suitability of the brine shrimp methods before they are used as a general bio-assay to test natural marine products for pharmacological activit...

The first synthesis of (+/-)-robinlin (1), a novel homo-monoterpene with strong bioactivity in the brine shrimp lethality test, was achieved by starting from 3-isobutyloxy-2,6,6-trimethyl-2-cyclohexen-1-one (2).

Cinnamomum species have long been used as spices. The preliminary bioactive constituent’s identification and brine shrimp lethality activities of ethanolic extracts of seven Cinnamomum species viz., C. travancoricum, C. walaiwarense, C. wightii, C. verum, C. sulphuratum, C. riparium, and C. perrottetii were evaluated in this study. The results of cytotoxic activity of the bark extracts of seven...

This study assessed the performance of a bioluminescent bacterial assay, the ToxScreen-II Test (Photobacterium leiognathi), in comparison to the brine shrimp (Artemia franciscana) nauplii lethality assay for the detection of toxicity associated with Aloe vera leaf gel extract and the organophosphate pesticide Mevinphos. In both bioassays, clear dose-response relationships were demonstrated for ...

The methanol extract of Cassia fistula seeds was investigated for potential antimicrobial activity against medically important bacterial, yeast and fungal strains. The antimicrobial activity was determined in methanol extract using the disk diffusion technique and the broth dilution method. The extract was effective on tested microorganism and the minimum inhibitory concentration (MIC) values w...