Bullous keratopathy (BK) entails an irreversible corneal edema secondary to the failure of the endothelial pump. Its poor response tomedical treatment and its disabling clinical symptomatology has given rise to the appearance of a range of medical treatments, although the majority of patients end up requiring a corneal or endothelial transplant. Recently, cross-linking has began to be hailed as...

PURPOSE One difficulty with Descemet's stripping automated endothelial keratoplasty (DSAEK) is air management during surgery and donor endothelial lamella centering. We evaluated the no-touch technique for donor centering and the use of a newly developed DSAEK donor adjuster. METHODS We evaluated the records of 12 consecutive patients (mean age 75.3 years) with bullous keratopathy who had und...

BACKGROUND AND OBJECTIVE To analyze the rationale for performing penetrating keratoplasty (PK) rather than Descemet's stripping automated endothelial keratoplasty (DSAEK) in patients with bullous keratopathy (BK) in Japan. PATIENTS AND METHODS A total of 136 eyes of 130 patients with consecutive BK were enrolled. Patients treated by DSAEK were categorized as the DSAEK group. The remaining pat...

Endothelial keratoplasty (EK) is the most exciting recent development in corneal transplantation. It has experienced surprisingly rapid growth in a very short period of time. One of the indications for EK is pseudophakic bullous keratopathy. However, concomitant intraocular lens (IOL) exchange, if indicated, may prove challenging. Some surgeons routinely perform IOL exchange with a scleral-fixa...

THE CONCEPT OF CXL In 1998, the proof-of-principle for corneal collagen cross-linking (CXL) was born from such a “simple” concept. Combining ultraviolet-A light and a chromophore (vitamin B2, riboflavin), the cornea could be stiffened within a mere half hour and progressive thinning diseases such as keratoconus could be halted.1,2 Although still considered a relatively new concept, CXL is now i...

PURPOSE To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder. METHODS To determine whether the disease expression was influenced by the genetic ancestry of CDK cases in native Mapuche of the northwest area of ...

PURPOSE To analyze endothelial cell density (ECD) decay after Descemet's stripping automated endothelial keratoplasty (DSAEK) and top hat keratoplasty (THPK) in patients with Fuchs' endothelial dystrophy (FED) and/or pseudophakic bullous keratopathy (PPBK). METHODS Patients underwent either THPK (n = 33) or DSAEK (n = 39) at the Erasmus Medical Center, Rotterdam. For each nonrandomized cohort...

The aim of the present study was to compare deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK) treatments for bullous keratopathy (BK). In total, 36 healthy New Zealand white rabbits were randomly divided into 3 groups termed the experimental, DLEK and PK groups. The experimental control group received no treatment. The DLEK and PK groups were observed for corneal a...