OBJECTIVE The NLRP3 inflammasome plays an important regulatory role in obesity-induced insulin resistance. NSAID activated gene-1 (NAG-1) is a divergent member of the TGF-β superfamily. NAG-1 Tg mice are resistant to dietary- and genetic-induced obesity and have improved insulin sensitivity. The objective was to examine whether NLRP3 inflammasome activity is associated with this observed phenot...

IL-18 function is neutralized in IL-18 binding protein transgenic (IL-18BP Tg) mice. First, we determined whether IL-18BP Tg mice are protected against ischemic acute kidney injury (AKI). Ischemic AKI was induced by bilateral renal pedicle clamping. IL-18BP Tg mice were functionally and histologically protected against ischemic AKI as determined by blood urea nitrogen, serum creatinine, and acu...

Abstract: materials can be fabricated by sintering of W-Cu composite powders. In this research W-20%wt Cu composite powderswas synthesized via a co-precipitation method. Precipitate obtained from a mixture of copper nitrate and ammoniumparatungstate (APT) in distilled water contained W-Cu compounds. This precipitate was washed, dried and calcinedat 550 of dried precipitate powder was determined...

OBJECTIVE When the availability of tetrahydrobiopterin (BH4) is deficient, endothelial nitric oxide synthase (eNOS) produces superoxide rather than NO (uncoupled eNOS). We have shown that the atherosclerotic lesion size was augmented in apolipoprotein E-deficient (ApoE-KO) mice overexpressing eNOS because of the enhanced superoxide production. In this study, we addressed the specific importance...

was significantly reduced. Isolated hearts and field-stimulated LV myocytes (3 Hz, 35°C) overexpressing GCH1 showed a faster relaxation and a PKA-mediated increase in the PLB Ser phosphorylated fraction and in the rate of decay of the [Ca ]i transient. RyR2 S-nitrosylation and diastolic Ca 2 leak were larger in mGCH1-Tg and ICa density was lower; nevertheless the amplitude of the [Ca2 ]i transi...

type2 diabetic is a metabolic disease in which is associated with the relative or absolute insulin deficiency, elevated blood glucose and impaired metabolism of carbohydrates, fat and protein. since fat and exercise is important to improve glycemic control in diabetic patients, so the purpose of this study was to evaluate the effect of interval training on a cycle ergometer on insulin resistanc...

objectives: turnip leaf has been used in folk medicine of iran for the treatment of diabetes. however,so far no scientific study has been done to support its use in traditional medicine. the present study was carried out to evaluate the possible hypoglycemic efficacy of aqueous extract of turnip leaf (aetl) in diabetic rats. materials and methods: alloxan-induced diabetic rats were orally treat...

Dietary n-3 fatty acids (FAs) may reduce cardiovascular disease risk. We questioned whether acute administration of n-3 rich triglyceride (TG) emulsions could preserve cardiac function and decrease injury after ischemia/reperfusion (I/R) insult. We used two different experimental models: in vivo, C57BL/6 mice were exposed to acute occlusion of the left anterior descending coronary artery (LAD),...

The present study aimed to explain the effect of Bay leaf and its isolated flavonoids glycosides on levels TC, TG, HDL-C, LDL-C VLDL-C in local Iraqi female rabbits. Isolation from were carried out, design included four groups (n=6): Control group-C fed with standard pellet diet; group1-G1 orally administrated daily dose 100 mg/ml/kg crude for 30 days; group2-G2 50 group3-G3 12.5 days. TG HDL-C...