Technology innovation engenders products of higher qualities and reduces production costs. This paper focuses on a two-sided platform tied with quality-improving hardware devices that are introduced sequentially. We analyze a monopolist’s dynamic pricing strategies facing decreasing future production cost and strategic buyers. Findings in both the traditional (buyer-side only) and two-sided bus...

Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization. This pathway maintains nutrients levels for vital cellular functions during periods of starvation and it provides cells with survival advantages under various stress situations. However, the mechanisms responsible for the induction and regulation of autophagy are poorly understood. The c-Jun NH2-terminal k...

A considerable amount of work has recently been applied to the development of processes to reduce negative environmental impacts of disposal products. Different waste reduction options such as direct reuse, repair, refurbishing, cannibalization, and remanufacturing were introduced to overcome these shortages. This paper studies an integrated system of manufacturing and remanufacturing using a c...

In this paper, we analyze the optimal introduction timing of a seller’s products targeted at segments that differ in their willingness to pay for quality. Past studies suggest that an introduction sequence of a high-quality product followed by a lower quality version of the product may mitigate the cannibalization effects of the low-quality product on profits from the high-quality product. We s...

In this paper, I investigate the question of how a …rm producing substitutes should coordinate price promotions of these products. I model price competition between two …rms, each producing two products that are horizontally di¤erentiated with respect to some characteristic. Consumers are divided into loyals, who always purchase their preferred product, and switchers who have heterogeneous pref...

Retailers did not immediately extend their business to the Internet environment, fearing that on-line activities could adversely impact their off-line sales. To facilitate assessment of the impact of on-line activities on offline sales, we develop a method that allows retailers to use readily available market data for making informed decisions. The proposed method determines (1) the extent to w...

Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I-deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I(-/-) mice died soon after birth as a resul...

In the face of cannibalization remanufactured products produced by independent remanufacturers (IRs), original equipment manufacturers (OEMs) can produce themselves to compete with or they authorize IRs cooperate because their seller reputation. This paper studies key factors that influence OEMs’ choice remanufacturing strategies. By establishing three two-stage models and comparing them, thres...