The present study was conducted to evaluate the hepatoprotective activity of hydroalcoholic extract of Tabernaemontana divaricata Linn.against paracetamol induced liver damage in rats. The hydroalcoholic extract of Tabernamontana divaricata Linn. (600mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference stan...

The production of cellulase-free xylanase was investigated with a locally isolated and identified strain, Cellulosimicrobium sp. MTCC 10645 in solid state fermentation. Different fermentation conditions were standardised for the growth and xylanase activity, the optimum being 72 h growth at pH 7.0, cultivation temperature 40°C and substrate to moisture ratio of 1:1.8 (w/v). Among different lign...

This study investigated the effect of morin on membrane bound enzymes and glycoproteins in normal and streptozotocin (STZ)-induced diabetic Wistar rats. Diabetes was induced in rats by an intraperitoneal injection of STZ, dissolved in citrate buffer (0.01 M, pH 4.5) and injected to overnight fasted rats with a dose of STZ 50 mg/kg. Morin was dissolved in carboxy methyl cellulose (CMC) at a dose...

Development of transdermal system mainly focused on formulation and characterization of monolithic matrix type transdermal drug delivery system of diltiazem hydrochloride for the treatment of mild to moderate hypertension. In this study, seven formulations were prepared in different ratio of film forming polymers. Formulations TDDS1 to TDDS7 were composed of carboxy methyl cellulose, polyvinyl ...

KMOE -2/05 cells, derived from a patient with acute erythremia, became benzidine-positive after the addition of cytosine arabinoside (CA). Radioimmunoassays using antihuman hemoglobin antibodies revealed an elevated amount of hemoglobin in the CA-exposed cells over that in the control cells (without CA). Isoelectric focusing of the CA-exposed cell lysate formed benzidine-positive foci in the po...

A total of five bacterial strains were isolated from soil samples of Selakui area of Dehradun, India, and were subjected to screening for their carboxy methyl cellulose (CMC) hydrolysis activity. Results revealed that, MJSH 1205 have maximum exocellulase activity and after fermentation at temperature 27°c, pH 7 and 1.5 % CMC concentration and 0.5% of urea as nitrogen source, bacterial strain MJ...

Background: Liver is one of the most important human organs and a sensitive target for chemicals that modulate biotransformation. The present study aimed to develop polyherbal formulation in form both capsules (solid dosage form) suspensions (liquid with combination powders Ricinus communis leaves, Allium sativum cloves, Piper nigrum seeds evaluated hepatoprotective activity. Methods: Three bat...

Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive effect of CC 4-16 mg/day was as great that other once-daily dosage regimens. has high first-pass metabolism and low oral bioavailability. bioavailability such drugs may be significantly improved if delivered through the buccal route; hence mucosal delivery one alternative methods systemic drug delivery....

the expression of endoglucanase gene and protein profile belonging to two fungal species, penicillium oxalicum 1sms and trichoderma viride 156ms with high cellulase enzyme activity, was investigated. fungal isolates were cultured on inducer cmc medium and then the amount of released sugar and protein were assayed every three days for a month, using arsenate molybdatereagent and bradford method,...