Detectable levels (>0.2 pinol/ID" cells) of one or more prostanoid species resultant to calcium ionophore A23187-induced biosynthesis from endogenous arachidonic acid were distributed in 28 cell lines derived from different histolÃ3gica!classes of lung tumors as follows: large cell undifferentiated carcinoma (3 of 3 cell lines); adenosquamous carcinoma (1 of 2 cell lines); squamous cell carcino...

Worldwide, lung cancer is the leading cause of cancer death in men and has surpassed breast cancer as the leading cause of cancer death in women in the latter part of 1980s. It is estimated that more than 500 000 new cases are diagnosed each year; approximately 15–20% of lung cancer patients have small cell lung cancer (SCLC) and the other patients have non-small cell lung cancer (NSCLC), such ...

Abstract Background Metastatic involvement of the breast is relatively rare and has an incidence 0.5–3%. Lesions that metastasize to may produce changes look similar those primary cancer on mammography, but they are more likely be multiple frequently bilateral. Case presentation A 38-year-old female complaining progressive proptosis with bilateral palpable lumps. She was referred imaging unit e...

Lung cancer is the leading cause of cancer-related death in the United States, with an average five-year survival rate of 15 percent. Smoking remains the predominant risk factor for lung cancer. Lung cancers are categorized as small cell carcinoma or non-small cell carcinoma (e.g., adenocarcinoma, squamous cell carcinoma, large cell carcinoma). These categories are used for treatment decisions ...

Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and th...

Background : Lung cancer is the leading cause of cancer-related mortality over worldwide. Although pathological diagnosis lung carcinoma limited as only small specimen available for diagnosis, availability targeted therapies has created a need precise subtyping non-small cell carcinoma. Several recent studies have demonstrated that use immunohistochemical markers can be helpful in differentiati...

Bombesin-like peptides have been implicated as autocrine growth factors influencing the pathogenesis and progression of some human lung carcinoma cells. To determine the pharmacologic and structural properties of the bombesin receptors expressed in human lung carcinoma cells, cDNA clones encoding a human gastrin-releasing peptide receptor (GRP-R) and a pharmacologically distinct neuromedin-B pr...

SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior r...

CONTEXT Pancreatic metastases are relatively common in advanced lung cancers (both small cell lung carcinoma and non-small cell lung carcinoma), but metastasis-induced acute pancreatitis is very unusual. CASE REPORT A 51-year-old woman with small cell carcinoma of the lung developed acute pancreatitis as the initial manifestation. Abdominal ultrasonography revealed multiple pancreatic metasta...

Recent studies indicate that the abnormal microenvironment of tumors may play a critical role in carcinogenesis, including lung cancer. We comprehensively assessed the number of stromal cells, especially immune/inflammatory cells, in lung cancer and evaluated their infiltration in cancers of different stages, types and metastatic characteristics potential. Immunohistochemical analysis of lung c...