Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct...

A PVC-based membrane containing cerium phosphate was developed. Unlike the cerium phosphate itself that acts as a cation exchanger, the membrane exhibited anion-exchange properties. Therefore, the utility of this compound as a sensory element for detection of molybdate ions was pursued. The response of molybdate selective electrode based on this membrane was perfectly linear in the concentr...

The hypothesis that C60 fullerene nanoparticles (C60) exert an antagonistic interactive effect on the toxicity of benzo[a]pyrene (BaP) has been supported by this investigation. Mussels were exposed to BaP (5, 50 & 100 ?g/L) and (C60–1 mg/L) separately in combination. Both shown co-localize secondary lysosomes hepatopancreatic digestive cells gland where they reduced lysosomal membrane stability...

The proton exchange membrane (PEM) fuel cell is a green energy producer which converts chemical energy to electricity in high yield. Alternatively, the vanadium redox flow battery (VRB) is one of the best rechargeable batteries because of its capability to average loads and output power sources. These two systems are modeled by Nernst equation and electrochemical rules. An effective energy gene...

Ferrocene derivatives are amongst the most promising electroactive organic electrolytes. The bottleneck problems of their application in aqueous redox flow batteries poor solubility and lower potential as well complexity modification methods to solve these problems. In this study, a benzenesulfonic acid group is easily introduced into ferrocene structure by mature diazotization reaction, synthe...

one of the problems encountering gerbera production is the decreasing flower quality and yield especially when grown in non-standard greenhouse coditions. in this research the effect of weekly humic acid (ha) (500 mg/l) spray was studied and compared with application of 2 solutions containing 3.5 and 7 meq/l of calcium along with the same concentration of ha on gerbera jamesonii l. it was demon...

background: spindle trees (euonymus japonica thunb.) growing in an industrial complex area containing pollutants is chronically injured thus need to build up their resistance. antioxidant enzymes and cell membrane stability have been widely used to differentiate stress tolerance. materials and methods: leaves of spindle trees from a clean control area (kijang) and an industrial area (onsan) whe...

platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. the nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. we exa...

background: hemophilia b is an x-linked hereditary disorder of blood coagulation system which is caused by factor ix (fix) deficiency. factor ix is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. replacement of factor ix with plasma-derived or recombinant factor ix is the conventional treatment for hemophilia b to raise the factor ix level...