نتایج جستجو برای: chemical synthesis

تعداد نتایج: 762625  

2013
Steen U. Hansen Gavin J. Miller Claire Cole Graham Rushton Egle Avizienyte Gordon C. Jayson John M. Gardiner

Heparin-like oligosaccharides mediate numerous important biological interactions, of which many are implicated in various diseases. Synthetic improvements are central to the development of such oligosaccharides as therapeutics and, in addition, there are no methods to elucidate the pharmacokinetics of structurally defined heparin-like oligosaccharides. Here we report an efficient two-cycle [4+4...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه رازی - دانشکده علوم 1390

in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...

M. Adeli, M. R. Aboutalebi, M. Shekari, S. H. Seyedein,

Combustion synthesis is a special thermophysico-chemical process applied for production of intermetallic compounds. In the present work, a reaction–diffusion numerical model was developed to analyze the combustion synthesis of aluminide intermetallics by self-propagating high-temperature synthesis process. In order to verify the reliability of the numerical model, an experimental setup was desi...

2005
Mark A. Behlke Eric J. Devor

It can fairly be said that synthetic oligonucleotides are the fuel that drives the engine of molecular biology. Nearly every technique in use today in molecular biology employs chemically synthesized DNAs or RNAs. This includes PCR, Real-Time PCR, DNA sequencing, site directed mutagenesis, single-nucleotide polymorphism (SNP) assays, microarrays, and the rapidly expanding world of small RNAs. U...

Journal: :Organic & biomolecular chemistry 2014
Jiabin Li Yuanyuan Li Qiaoqiao He Yiming Li Haitao Li Lei Liu

One of the rising demands in the field of protein chemical synthesis is the development of facile strategies that yield the protein in workable quantities and homogeneity, with fewer handling steps. Although the native chemical ligation of peptide hydrazides has recently been shown to be useful for the chemical synthesis of proteins carrying acid-sensitive modification groups, previous hydrazid...

2017
Holly A. Reeve Philip A. Ash HyunSeo Park Ailun Huang Michalis Posidias Chloe Tomlinson Oliver Lenz Kylie A. Vincent

The present study considers the ways in which redox enzyme modules are coupled in living cells for linking reductive and oxidative half-reactions, and then reviews examples in which this concept can be exploited technologically in applications of coupled enzyme pairs. We discuss many examples in which enzymes are interfaced with electronically conductive particles to build up heterogeneous cata...

2016
Yi-Chao Huang Ge-Min Fang Lei Liu

Protein chemical synthesis offers useful and otherwise-difficulty-to-obtain biomacromolecules for biological and pharmaceutical studies. Recently, the hydrazide chemistry has drawn attentions in this field as peptide or protein hydrazides can be used as key intermediates for different synthesis and modification purposes. Besides being a traditional bioorthogonal chemical handle, a hydrazide gro...

2005
W. R. J. D. GALLOWAY F. G. GLANSDORP D. M. MARSDEN R. L. NICHOLSON R. J. SPANDL G. L. THOMAS E. E. WYATT

This article covers the diversity oriented synthesis (DOS) of small molecules in order to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high throughput screening approach useful for chemical genetics and drug discovery programmes. Nature synthesizes a rich structural diversity of small molecules, however, unfortunately, there are some disadvant...

Journal: :Trends in Glycoscience and Glycotechnology 1996

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