Chlorhexidine gluconate is an effective bactericidal agent and broad-spectrum antimicrobial drug. It has been extensively researched and is the “gold standard” antimicrobial in oral hygiene. Chlorhexidine is useful in many clinical disciplines including periodontics, endodontics, oral surgery and operative dentistry. Introduction Chlorhexidine gluconate (chlorhexidine) is a broad-spectrum antim...

[a] HemaClear ® , a self-contained, sterile, exsanguinating tourniquet face. Chemical burn was also reported in a 4 year old boy who underwent general anesthesia for elective orchidopexy; within a few hours, the child developed erythema and blistering around the upper buttocks and natal cleft region. The author recommended saline rinsing after antisepsis [4]. In 1995, contact dermatitis involvi...

Methods Alcohol proportion and bactericidal agents (e.g. CHG (chlorhexidine gluconate), BAC (benzalkonium chloride), PHMB and OCT (Octenidine)) were compared to determine suitability for surgical hand antisepsis. PHMB-containing handrub was then tested in accordance with European Norm (EN). To further evaluate the hand antiseptics or bactericidal agents, their cytotoxicity was investigated with...

BACKGROUND Diseases that affect the buccal cavity are a public health concern nowadays. Chlorhexidine and nystatin are the most commonly used drugs for the control of buccal affections. In the search for more effective antimicrobials, nanotechnology can be successfully used to improve the physical chemical properties of drugs whilst avoiding the undesirable side effects associated with its use....

Methods The study was conducted during 2010 in a general ICU and in a Cardiology ICU of a medium sized hospital in Sao Paulo, Brazil. CLABSI was defined according to the National Healthcare Safety Network definition. The set of measures was introduced in July 2010 and included reinforcement of prevention measures, switching opaque valve connectors to a transparent version, introduction of chlor...

Background Bloodstream Infection and Central Line-Associated Bloodstream Infection (BSI/CLABSI) in Intensive Care Units (ICUs) are associated with clinical and economic burden. Chlorhexidine gluconate body washing with washcloths (CHG-WC) has been described as potentially effective towards reducing the spread of infection. Current systematized evidence has not fully ascertained the impact of CH...

Data sources Clinical trials in any language were identified by searching Medline (1966–2001), CINAHL (1982–2001), Doctoral Dissertation Abstracts (1861–2001), International Pharmaceutical Abstracts (1970–2001), EMBASE/Excerpta Medica, Lexis-Nexus, Web of Sciences, and the Cochrane Library; hand searching Index Medicus (1960–65) and scientific meeting programmes and proceedings; reviewing bibli...

PURPOSE To determine the bactericidal efficacy of a new topical antiseptic for preoperative skin preparation, olanexidine gluconate (development code: OPB-2045G), against transient or resident bacterial flora on the skin of cynomolgus monkeys. METHODOLOGY After measuring baseline bacterial counts on test sites marked on the abdomens, we applied olanexidine, chlorhexidine or povidone-iodine. A...

OBJECTIVE The aim of this study was to assess in vitro the antimicrobial activity of 2% chlorhexidine gel against Enterococcus faecalis , comparing it to other endodontic irrigants (2% chlorhexidine liquid and 5.25% sodium hypochlorite). STUDY DESIGN Eighty roots of human mandibular premolars were prepared by serial instrumentation technique, autoclaved, and contaminated for 7 days with E fae...