Chromosomes (Chr) 10 and 16 of the Dahl salt-sensitive (S) rat harbor quantitative trait loci (QTLs) for blood pressure (BP). To facilitate gene discovery of these QTLs, gene profiling based on microarrays was combined with fine QTL mapping to identify potential candidate genes that are differentially expressed. First, the region harboring the BP QTL on Chr 16 was narrowed by comparative congen...

Our purpose was to define quantitative trait loci (QTL) for blood pressure that differ between two widely used hypertensive rat strains, the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR). A genome scan was done on an F(2) (S x SHR) population fed 8% NaCl for 4 wk. Three blood pressure QTL were detected, one on each of rat chromosomes (chr) 3, 8, and 9. For the chr 3 Q...

Constraint Handling Rules (CHR) is an elegant, high-level programming language based on multi-headed, forward chaining rules. A distinguishing feature of CHR are propagation rules. To avoid trivial non-termination, CHR implementations ensure a CHR rule is applied at most once with the same combination of constraints by maintaining a so-called propagation history. The performance impact of this ...

To clarify the genetic mechanisms of stroke susceptibility in the stroke-prone spontaneously hypertensive rat (SHRSP), a quantitative trait locus (QTL) analysis was performed. Using 295 F2 rats of a cross between SHRSP/Izm and SHR/Izm, 2 major QTLs for stroke latency under salt loading were identified on chromosomes (chr) 1 and 18. Evaluation of 6 reciprocal single and double congenic rats for ...

Constraint Handling Rules (CHR) is both an effective concurrent declarative programming language and a versatile computational logic formalism. CHR has its roots in constraint logic programming and concurrent constraint programming, but also integrates ideas from multiset transformation and rewriting systems. CHR programs consist of guarded reactive rules that transform multisets of constraints...

Previously we presented suggestive evidence from an F2 segregating population for an interaction on blood pressure (BP) between quantitative trait loci (QTL) on rat chromosomes (Chr) 2 and 10. To prove the existence of such an interaction, we developed congenic strains for Chr 2 and 10 by introgressing the low BP QTL alleles into the Dahl salt-sensitive (S) strain. A double congenic strain was ...

s | 67 PM459 Brain Network Characteristics of Individuals at Clinical High Risk for Psychosis in between Normality and Psychosis: A Combined Structural and Functional Imaging Study Soo-Hee Choi, Jun Soo Kwon Seoul National University, Republic of Korea Abstract Objective: In an effort to improve early recognition and intervention in patients with schizophrenia (SZ), individuals at clinical high...

s | 67 PM459 Brain Network Characteristics of Individuals at Clinical High Risk for Psychosis in between Normality and Psychosis: A Combined Structural and Functional Imaging Study Soo-Hee Choi, Jun Soo Kwon Seoul National University, Republic of Korea Abstract Objective: In an effort to improve early recognition and intervention in patients with schizophrenia (SZ), individuals at clinical high...

The cell cycle genes homology region (CHR) has been identified as a DNA element with an important role in transcriptional regulation of late cell cycle genes. It has been shown that such genes are controlled by DREAM, MMB and FOXM1-MuvB and that these protein complexes can contact DNA via CHR sites. However, it has not been elucidated which sequence variations of the canonical CHR are functiona...

AIM High rates of anxiety have been observed in youth at clinical high risk (CHR) of developing psychosis. In CHR, anxiety often co-occurs with depression, and there is inconsistent evidence on anxiety in relation to transition to psychosis. The aim of this study was to examine: (i) the prevalence of anxiety disorders in individuals at CHR; (ii) clinical differences between those with and witho...