Liver cirrhosis and hepatocellular carcinomas are major health problems of chronic hepatitis B virus (HBV) infection. To date, rare model has reproduced liver fibrosis associated with long-term HBV infection which in turn has hindered both the understanding of HBV biology and the development of new treatment options. Here, using adeno-associated virus serotype 8 (AAV8) mediated delivery of a 1....

Hepatitis B virus (HBV) infection remains a global public health problem with changing epidemiology due to several factors including vaccination policies and migration. This Clinical Practice Guideline presents updated recommendations for the optimal management of HBV infection. Chronic HBV infection can be classified into five phases: (I) HBeAg-positive chronic infection, (II) HBeAg-positive c...

results patients’ age ranged from 15 to 65 years (mean = 35.54 ± 14.85). thirty four (1.0%) of the subjects were positive for hbsag, of whom, 2.9 % (1 of 34 cases) were also positive in pcr-based screening. elisa tests for hbeag, hbeab, and hbcab igm were positive in one (2.9 %), 27 (79.4%) and one (2.9 %) cases, respectively. conclusions according to our results, hbsag was positive in 0.53 of ...

Chronic infection with hepatitis B virus (HBV) affects about 5% of the world population (1). In Western Europe, Australia and the USA prevalence of chronic carriers of hepatitis B surface antigen (HBsAg) is less than 1% of the population. Among human immunodeficiency virus (HIV) infected individuals this prevalence is approximately 10 fold higher (2). Until recently, studies on HBV infection in...

BACKGROUND Sub-Saharan Africa carries a high burden of co-infection with HIV-1 and hepatitis B virus (HBV). In this region, individuals with HIV-1/HBV co-infection on antiretroviral therapy (ART) frequently receive lamivudine as the only agent active against HBV, raising concerns for development of HBV resistance to lamivudine. We aimed to determine the prevalence, clinical, and virologic outco...

Chronic hepatitis C virus (HCV) infection combined with occult hepatitis B virus (HBV) infection has been associated with increased risk of hepatitis, cirrhosis and hepatocellular carcinoma. This study aimed to determine the prevalence of occult HBV infection among Egyptian chronic HCV patients, the genotype and occurrence of surface gene mutations of HBV and the impact of co-infection on early...

With up to 400 million affected people worldwide, chronic hepatitis B virus (HBV) infection is still a major health care problem. During the last decade, several novel therapeutic approaches have been developed and evaluated. In most regions of the world, interferon-α (IFN-α), and nucleos(t)ide analogues are currently approved. Despite major improvements, none of the existing therapies is optim...