UNLABELLED Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level. Here, we present an analysis of CME in the human fungal pathogen Candida albicans that shows the same modular structure as those in other fungi and mammalian cells. Intriguingly, C. albicans is perfectly viable in the absence of Arp2/3, an essential component of C...

n engl j med 366;12 nejm.org march 22, 2012 1069 action led physicians’ organiza­ tions and the pharmaceutical in­ dustry to adopt increasingly re­ strictive codes of conduct related to industry support of continuing medical education (CME). The Ac­ creditation Council for Continu­ ing Medical Education (ACCME), which accredits CME providers, progressively developed an aggres­ sive system of id...

The magnetic field topology at the coronal mass ejection (CME) source regions has been one of the major focuses of CME initiationmodels.While the ‘‘breakout’’ model requires a quadrupolar magnetic topology in the solar corona to enable an eruption, other models have shown that a bipolar magnetic topology can be the source region of a CME. In this paper, we use observational data and a potential...

More and more evidence indicates that “EIT waves” are strongly related to coronal mass ejections (CMEs). However, it is still not clear how the two phenomena are related to each other. We investigate a CME event on 1997 September 9, which was well observed by both EUV imaging telescope (EIT) and the high-cadence MK3 coronagraph at Mauna Loa Solar Observatory, and compare the spatial relation be...

We present a hybrid combination of forward and inverse reconstruction methods using multiple observations of a coronal mass ejection (CME) to derive the 3D ’true’ Height-Time plots for individual CME components. We apply this hybrid method to the components of the 31 Dec 2007 CME. This CME, observed clearly in both the STEREO A and STEREO B COR2 white light coronagraphs, evolves asymmetrically ...

A major goal of continuing medical education (CME) is to enhance the performance of the learner. In order to accomplish this goal, careful consideration and expertise must be applied to the three primary ingredients of CME planning: assessing learner needs, programme design and outcome measurement. Traditional methods used to address these three components seldom result in CME initiatives that ...

A continuous microwave equipment (CME) has been successfully developed in order to achieve an extremely rapid and mass production for ZSM-5 and NaY zeolite. A precursor mixture for synthesis of ZSM-5 was prepared by mixing aluminosilicate gel with a nanoseed solution obtained under microwave irradiation, and pumped continuously into the CME. Duration time in the CME was 5 min to accomplish the ...

Performance Improvement CME (PI CME) is an educational activity in which clinicians retrospectively assess their current clinical practice, choose areas for improvement and implement interventions based on treatment guidelines and health care standards, and then re-evaluate their clinical practice to assess the improvements made. This PI CME activity focuses on improving the safety and efficacy...

In this issue of Blood, we are pleased to introduce a new Continuing Medical Education (CME) feature, appearing monthly. For many years ASH has provided CME credits for the annual meeting and other educational meetings sponsored by the society. In surveying society members, more CME activities has been a frequent request. To this end, the Society and Blood explored offering CME credits for sele...