Lead poisoning is the most significant preventable disease of environmental origin. Neurodevelopment is highly complex and there are numerous opportunities for lead to interfere with normal development. Lead acetate can disrupt the action of the CNS and the development of dendrites and axons. The present study was carried out to assess the effect of low-level lead exposure on memory and learn...

BACKGROUND Ficus carica Linn. is reported to possess variety of activities, but its potential in CNS disorders is still to be explored. OBJECTIVE The present study was carried out to evaluate the CNS depressant activity of aqueous acetonic extract of Ficus carica Linn on different models in mice. MATERIALS AND METHODS The aerial parts of the plant Ficus carica L. were extracted with aqueous...

Fruits of Phoenix sylvestris Roxb. (Arecaceae) are used to treat back pain, toothache, headache, arthritis, nervous debility and as sedative. The aim of this study was to evaluate the antinociceptive and neuropharmacological activities of methanol extract of P. sylvestris fruit pulp (MEPS). The antinociceptive activity of MEPS was evaluated by heat-induced (hot plate, tail immersion test) and c...

INTRODUCTION alcohol is a psychotropic depressant of the central nervous system (CNS) that promotes simultaneous changes in several neuronal pathways, exerting a profound neurological impact that leads to various behavioral and biological alterations. OBJECTIVES to describe the effects of alcohol on the CNS, identifying the signaling pathways that are modified and the biological effects resul...

The project work was designed to investigate the phytochemical and selected pharmacological activities (anti-diarrheal, analgesic, neuropharmacological behavior anthelmintic) of leaves Sanchezia nobilis. Hook. F. (Family: Acanthaceae). From its analysis we found presence reducing sugar, combined phenolic compounds, tannins, flavonoids, carbohydrates, gums, steroids, alkaloids, glycosides terpen...

The effects of halothane, isoflurane and enflurane were compared on three CNS excitatory synaptic pathways in vitro, to determine whether selective actions described in vivo result from differential effects on anatomically distinct cortical pathways and neurone populations. Halothane (0.25-1.25 vol%) depressed postsynaptic excitability of CA1 pyramidal neurones in response to activation of stra...