BACKGROUND AND AIMS Butyrate oxidation by colonocytes is impaired in ulcerative colitis. This study examined the activity of enzymes involved in butyrate oxidation in ulcerative colitis. METHODS Activities of mitochondrial acetoacetyl coenzyme A (CoA) thiolase, crotonase and beta-hydroxy butyryl CoA dehydrogenase were estimated spectrophotometrically in rectosigmoid mucosal biopsies from pati...

THE EFFECTS OF COOKED WHOLE ASPARAGUS (ASPARAGUS OFFICINALIS L.) AND ITS PURIFIED BIOACTIVE, RUTIN, ON SYMPTOMS OF DSS-INDUCED ACUTE COLITIS AND RECOVERY IN C57BL/6 MICE Jenifer Thi Lu Advisor: Dr. Lindsay Robinson University of Guelph, 2013 This thesis explored the effects of cooked whole asparagus and its purified bioactive, rutin, on colitis symptoms and disease progression in mice using a c...

CONTEXT Nonsteroidal anti-inflammatory drugs are considered one of the most important causes of reactivation of inflammatory bowel disease. With regard to selective cyclo-oxygenase 2 inhibitors, the results are controversial in experimental colitis as well as in human studies. OBJECTIVES The aim this study is to compare nonsteroidal anti-inflammatory drugs effects, selective and non selective...

AIMS To determine: (1) whether there is an association between collagenous colitis and coeliac disease or lymphocytic colitis; (2) the distribution of lymphocyte subsets and macrophages in the lamina propria and surface epithelial layer in collagenous colitis; and (3) the colorectal distribution of the disease and whether a mucosal biopsy specimen, using a flexible sigmoidoscope, is sufficient ...

the aim of this study was to test the therapeutic efficacy of sodium alginate in a rat model of trinitrobenzene sulfonic acid (tnbs)-induced inflammatory bowel disease. this experiment was carried out using 77 sprague-dawley rats which were divided into six groups; normal, control, prophylactic, therapeutic and two experimental groups. rats were sacrificed 1, 2, 3 and 6 weeks after colitis indu...

inflammatory bowel diseases are one of the important reasons of the referral to gi practitioners in our country and ulcerative colitis is the more frequent type of these disease in iran. in this study 200 cases of ulcerative colitis, which has been referred to imam khomeini hospital during that last 5 year, were studied. data was collected using the patient's records and face to face inter...

Purpose: In this study, the effect on heart, kidneys and liver organs in TNBS-induced Ulcerative colitis was investigated. Method: Twenty mice were randomly divided into two groups, which included normal group and model group. The model of chronic colitis was induced by 50% TNBS. The model of chronic colitis was verified by body weight, H&E staining. Heart, kidneys and liver organs were tested ...

 The aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. The plasma concentrations of the four flavonoids were determined...