نتایج جستجو برای: colorectal cancers
تعداد نتایج: 164124 فیلتر نتایج به سال:
PURPOSE The BRAF gene encodes a serine/threonine kinase and plays an important role in the mitogen-activated protein kinase signaling pathway. BRAF mutations in sporadic colorectal cancer with microsatellite instability (MSI) are more frequently detected than those in microsatellite stable cancer. In this study, we sought to compare the frequencies of BRAF mutations in sporadic colorectal cance...
Urokinase-type plasminogen activator (u-PA) is a serine protease that has been implicated in cancer invasion and metastasis. We quantitated u-PA levels in normal colorectal mucosa, adenomatous polyps, and colorectal cancers and correlated these levels with clinicopathological features and patient survival. Detergent extracts were prepared from 133 colorectal cancers, 133 corresponding colorecta...
Abstract Background: Colorectal cancer is one of the most common cancers worldwide. It is the third common cancer and the second leading cause of death from cancers in the developed countries. First degree relatives of colorectal cancer patient have a 2-3 fold higher risk to develop disease. Planning for Prevention from disease at this group needs to review their current needs and assess the...
Background and Objective : Lymphovascular involvement is the main and most important prognostic factor in colorectal cancer. This study aimed to evaluate the relationship of morphological differentiation and lymph/vascular involvement. Materials and Methods: In this cross-sectional study, the pathological results of 52 colectomy patients between 2006 and 2011 in Emam-Reza and Be’sat Hospita...
Background: Colorectal cancer is the fourth most common cancer in the world. It is the third largest risk factor for cancer individuals. The number of new cases is rising since 1975. Hyper activities of EGFR family have been reported in various cancers. The purpose of this study was to investigate the expression levels of HER2 in colorectal cancer and its possible association with advanced stag...
Colorectal cancer is a major cause of morbidity and mortality. About 15 - 20% of all colorectal cancers are familial. Hereditary nonpolyposis colorectal cancer is an inherited cancer predisposition syndrome. It is caused by mutations in mismatch repair genes, predominantly MSH2 and MLH1. Although hereditary nonpolyposis colorectal cancer accounts for a minority of colorectal cancers, the mutati...
Background: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present...
OBJECTIVES To estimate the number and proportion of cancers occurring in Australia in 2010 attributable to consumption deficits in fruit, non-starchy vegetables and dietary fibre. METHODS We estimated the population attributable fraction (PAF) for cancers causally associated with inadequate intake of fruit and non-starchy vegetables (oral cavity, pharynx, oesophageal squamous cell carcinoma, ...
OBJECTIVES To estimate the proportion and numbers of cancers in Australia in 2010 attributable to consuming red/processed meat. METHODS We estimated the population attributable fraction (PAF) for cancers causally associated with red/processed meat consumption (colon, rectum) using standard formulae incorporating prevalence of consumption (1995 National Nutrition Survey), relative risks associ...
OBJECTIVE Screening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and le...
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