Ultrasound is a good tool for theranostics due to have multi-potency both of diagnostics with sonography and therapeutics with high intensity focused ultrasound (HIFU). In addition, microbubbles and nanobubbles are utilized as not only contrast imaging agent but also enhancer of drug and gene delivery by combination of ultrasound. Recently, we developed novel liposomal nanobubbles (Bubble lipos...

Recent technological advances in the synthesis and design of magnetic nanoparticles (MNPs) have opened various avenues for these materials in medical applications. These technologyfacilitated features as well as intrinsic features make MNPs as an ideal choice in different medical diagnostic and treatment applications. Some of important attributes of MNPs that make MNPs great choice for medical ...

Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle (SPION)-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential bi...

Magnetic nanoparticles (MNPs) have demonstrated their great potentials in medical applications. Technology advancements in synthesis and modification of nanoscale materials have advanced the development of different medical applications of MNPs. This paper reviews the main chemical and physical properties of MNPs important in medical applications. Pharmacokinetics and cellular adsorb of MNPs ar...

In the past decades, there is a growing interest in the design and synthesis of composite microspheres with a dielectric solid sphere (e.g., silica, polystyrene) covered by metallic and their corresponding metal oxides shell, such as copper[1], gold[2], silver[3,4], iron oxide[5], zinc oxide[6,7], titanium oxide[8,9] and zirconium dioxide[10]. Such materials may exhibit a few unique electrical,...

Magnetic-mediated hyperthermia (MMH) is a promising local thermotherapy approach for cancer treatment. The present study investigated the feasibility and effectiveness of MMH in esophageal cancer using a rabbit tumor model. The therapeutic effect of two hyperthermia approaches, magnetic stent hyperthermia (MSH), in which heat is induced by the clinical stent that is placed inside the esophagus,...

The effects of SR-4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cell cytotoxic agent, were assayed against the FSaIIC murine fibrosarcoma in vitro and in vivo alone and in conjunction with hyperthermia and radiation. In vitro, a concentration of 500 microM of SR-4233 upon exposure of the cells for 1 h decreased the survival of hypoxic cells by about 1 log more than euoxic cells at 3...

Since cancer cells produce large amounts of lactate via aerobic glycolysis and since an acidic pH has been shown to selectively enhance the cytotoxic effects of hyperthermia, we are examining the influence of cell exposure to drugs which inhibit lactate transport and lower intracellular pH upon cytotoxic effects of hyperthermia. Quercetin, a bioflavonoid that produces lactate transport inhibiti...