Abstract Background and Aims Osteoporosis in hemodialysed (HD) patients with Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) is a debilitating clinical condition complex therapeutic management. In fact, most of the drugs commonly used to counteract osteoporosis are generally contraindicated when Glomerular Filtration Rate (GFR) lower than 30 ml/min. Denosumab (DMab) monoclonal antibody...

Abstract Background In patients with heart failure an increased risk of fracture-related mortality has been reported. A growing body evidence suggests that, (HF) itself may be related to disturbances in bone metabolism, but the exact mechanism remains unclear. HF previous studies indicated a loss renal function and alterations micro-architecture, clinical relevance Purpose We aimed evaluate ass...

BACKGROUND Vitamin D supplements are recommended in individuals with vitamin D insufficiency and established osteoporosis to reduce risk of fracture and falling. Active vitamin D metabolites have been found to be more effective for fall prevention than native vitamin D. OBJECTIVES The aim of this study was to compare the efficacy of strontium ranelate in combination with alfacalcidol and stro...

BACKGROUND In patients with severe emphysema, bone mineral density (BMD) is reduced and the risk of osteoporosis is increased. STUDY OBJECTIVES To identify the impact of lung volume reduction surgery on BMD. DESIGN Prospective cohort study. SETTING University hospital. PATIENTS AND INTERVENTIONS Forty emphysematous patients, all receiving oral steroid therapy, underwent bilateral lung v...

INTRODUCTION Patients with rheumatoid arthritis (RA) have an increased frequency of osteoporosis, mainly because of increased bone resorption. Reduction of disease activity is suggested to reduce bone remodelling. It might also be possible that prednisolone treatment could cause this effect because prednisolone has been shown to arrest the development of joint destruction in early RA. Therefore...

The purpose of the present study was to investigate the influence of diets supplemented with anionic salts on bone metabolism of dairy goats and sheep. Twelve Saanen goats and 12 Ostfrisean milk sheep (fourth lactation) were divided into 2 groups each [sheep control (SC), goat control (GC); sheep anionic salts (SA), goat anionic salts (GA)]. Each group was fed a different diet in the last 10 d ...

Background: CDSO is a condition affecting predominantly the mandible and long bones of young females, characterised by episodes of intractable pain on a background of chronic discomfort. The aetiology is unknown, but the bone sclerosis is associated with abnormal osteoblast and osteoclast function. Methods: We report 3 cases in which symptoms and biochemical markers responded to treatment with ...

Introduction: Le présent travail se propose d'étudier la relation entre les hormones sexuelles, notamment l'œstradiol et l'indice de l'œstradiol libre, le sulfate de déhydroépiandrosterone et la sex hormone binding globulin, les marqueurs de remodelage osseux et la densité minérale osseuse chez une population de femmes marocaine ménopausées. Méthodes: Il s'agit d'une étude transversale, menée s...

OBJECTIVES To undertake an epidemiological survey of the prevalence of radiological chondrocalcinosis (CC) of the lower limbs in the elderly Italian population of the Pro.V.A. study. METHODS Knee and pelvic basin radiographs were performed on 3099 subjects aged 65 and older, residing in the Veneto Region of Italy (Rovigo and Camposampiero areas). Two readers independently analysed the knee, c...

BACKGROUND The efficacy control for the treatment of bone metastases in breast cancer is difficult and usually initiated later and with longer time between treatment cycles than the restaging of visceral or soft tissue metastases. The amino-terminal propeptide (PINP) of type I collagen as a biochemical indicator of bone turnover might facilitate early and valid disease surveillance. The utility...