The Serum CrossLaps One Step ELISA is a sandwich assay using two monoclonal antibodies specific for a beta-aspartate form of the epitope EKAHDGGR derived from the carboxy-terminal telopeptide region of type I collagen alpha1-chain. Our objective was to assess the clinical value of the Serum CrossLaps assay for monitoring antiresorptive therapy in osteoporosis treatment. Samples obtained from po...

at pH 6.5, 7.3, and 8.0 are summarized in Fig. 1. Intermediate results were seen at pH 7.0 and 7.6 (not shown). Immediately after the pH manipulation, the b-crosslaps increased 0.2–6.6% (P .0.05). After 2 days, all samples exhibited a significant decrease of the b-crosslaps concentrations. In the control samples, b-crosslaps decreased by 12% at 37 °C and by 5% at room temperature on the second ...

Markers of bone turnover are becoming an important tool for practitioners in the management of osteoporosis. Therefore, it is essential to establish a reference database of the markers before using them in various clinical settings. A total of 785 individuals (37% males, 63% females) without apparent or suggested abnormalities affecting bone mass were randomly selected from 13 clusters in Bushe...

PURPOSE Reports on clinical measurements of bone mineral density (BMD) in prostate cancer patients undergoing intermittent androgen suppression therapy (IAS) that allows for hormonal recovery between treatment cycles indicate decreased osteoporosis compared to continuous androgen suppression therapy (CAS). In the present study the effect of IAS on bone metabolism by determinations of CrossLaps,...

To the Editor: Accurate assessment of bone resorption may be of significant value for selecting women for antiresorptive therapy, monitoring of therapeutic response in treated individuals, and predicting fracture risk (1 ). This goal may be facilitated by measurement of biochemical markers of bone metabolism. The Serum CrossLaps One Step ELISA measures fragments derived from the C-terminal telo...

serum assay seems to be more restrictive than the urinary assay for detecting products derived from the telopeptide region of collagen type I. The decrease in bone remodeling that occurs in older girls with respect to younger girls is a generally accepted fact. In accordance with the results found in this work in b-CTX and bAP concentrations, it would be possible suggest that serum b-CTX assay ...

SUMMARY OBJECTIVE: In this study, we aimed to determine fibroblast growth factor 23, soluble alpha klotho, osteocalcin, indoxyl sulphate, sclerostin, Procollagen 1 N Terminal Propeptide, and beta-CrossLaps levels in hemodialysis peritoneal dialysis patients, compare the of these markers among as well healthy individuals. METHODS: The study included 30 23 patients who were followed-up for at lea...

BACKGROUND To evaluate effects of neoadjuvant chemotherapy on the bone turnover markers of preoperational breast cancer patients. METHODS Forty-one breast cancer patients (29 premenopausal and 12 postmenopausal) and 60 healthy women (30 premenopausal and 30 postmenopausal) aged 30-64 years, were evaluated for their bone status. Serum levels of the bone formation markers PINP and BAP, as well ...

UNLABELLED INTRODUCTION. Menopausal osteoporosis is a disease of older age, and its development is related to the cessation of ovarian function together with a number of risk factors. Monthly dosing regimens are welcomed by women because of higher satisfaction and better adherence. This study was aimed at assessing the therapeutic effect of ibandronate given once a month to women with postmenop...