نتایج جستجو برای: cytogenetic aberrations
تعداد نتایج: 27335 فیلتر نتایج به سال:
Multiple myeloma (MM) is a genetically heterogeneous disease with diverse clinical characteristics and outcomes. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for the detection of cytogenetic aberrations in MM patients. In the present study, MLPA analysis was applied to analyze cytogenetics of CD138 tumor cells of 59 MM samples, ...
Conventional banding techniques can characterize chromosomal aberrations associated with tumors and congenital diseases with considerable precision. However, chromosomal aberrations that have been overlooked or are difficult to analyze even by skilled cytogeneticists were also often noted. Following the introduction of multicolor karyotyping such as spectral karyotyping (SKY) and multiplex-fluo...
The aim of this study was simultaneously to evaluate the potential influence of cytogenetic, immunophenotypic and cell culture studies in the evolution of the myelodysplastic syndromes (MDS) with particular attention to the value of the two latter features in predicting the outcome of those patients in which karyotypic information is normal or not available. A series of 77 newly diagnosed patie...
Acute myeloid leukemia (AML) is a heterogeneous disease with respect to clinical prognosis and acquired chromosomal aberrations. After routine banding cytogenetic analysis 45% of AML patients show a normal karyotype (NK-AML). For a better understanding of development and progression in AML, it is important to find markers which could be primary genetic aberrations. Therefore, in this study 31 p...
OBJECTIVE Multiple myeloma (MM) is characterized by the accumulation and proliferation of malignant plasma cells, secreting monoclonal immunoglobulins and genetic abnormalities in MM have implications for disease progression and survival. In the present study, we investigated the frequency of chromosomal abnormalities (CA) in Turkish patients with MM, using interphase FISH and CC and evaluated ...
Attention-deficit/hyperactivity disorder (ADHD) is the most common psychiatric condition with onset in childhood, and in more than 50% of cases it persists into adulthood as a chronic disorder. Over five million methylphenidate (MPH) prescriptions were issued in the USA in 2003, mostly for children. A previous report [R.A. El-Zein, S.Z. Abdel-Rahman, M.J. Hay, M.S. Lopez, M.L. Bondy, D.L. Morri...
Multiple myeloma (MM) is a heterogeneous clonal malignancy of plasma cells characterized by cytogenetic and molecular abnormalities. Chromosomal abnormalities are present at diagnosis can evolve during the progression MM. Metaphase karyotyping fluorescence in situ hybridization considered standard diagnostic procedures performed clinical practice. These test results required to determine Revise...
Cytogenetic abnormalities are found in 50-60% of newly diagnosed acute myeloid leukemia (AML) of adult patients. Cytogenetic analysis of bone marrow leukemic cells is an important pre-treatment evaluation for a correct prognostic stratification of patients, that permit to separate AML patients in three broad prognostic categories: high, intermediate and low risk. The determination of cytogeneti...
Aim. To study the frequency and spectrum of cytogenetic disorders in Triticum aestivum L., induced by effect moderate high concentrations N-nitroso-N-methylurea. Methods. The seeds winter wheat cultivars Albatros odeskyi Zymoiarka were treated with water solution N-nitroso-N-methylurea such as 0.005 %, 0.01 0.025 %. A analysis cells a root meristem was made help an anatelophase method. Results....
X-ray pulses (full width at half maximum ∼ 90 ns, dose rate 107 Gy s−1) were used to irradiate the monolayer of peripheral blood mononucleated cells using PF-2kJ kilojoule plasma focus device. Four different exposure conditions evaluated 5, 10, 20, and 40 pulses, with mean measured by TLD-100 being 0.12 ± 0.02 mGy, 0.14 0.03 0.22 0.06 0.47 0.09 respectively. Cytogenetic analysis showed an incre...
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