نتایج جستجو برای: cytogenetic aberrations
تعداد نتایج: 27335 فیلتر نتایج به سال:
objective: chromosomal aberrations are common causes of multiple anomaly syndromes. recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques. materials and methods: in this retrospective study, the incidences of chromosomal aberrations were evaluated in a six year period from 2005 to 2011 i...
ObjectiveTo test the hypothesis that telomere shortening and/or loss are risk factors for infertility.DesignRetrospective analysis of status in patients with infertility using conventional cytogenetic data collected prospectively.SettingAcademic centers.Patient(s)Cytogenetic slides cultured peripheral lymphocytes from 50 undergoing fertility treatment and 150 healthy donors, including 100 donor...
The study utilized molecular-genetic, cytogenetic, and statistical analyzes methods. A cytogenetic molecular genetic analysis of the inhabitants villages Amangeldy, Belbulak, in whose territory warehouses unused pesticides are located, was carried out. Residents Basshi village, on which there no products disposal pesticides, were taken as control. Cytogenetic showed a high level chromosomal abe...
conclusions it was demonstrated that the presence of del6q21 in b-cll patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease. results deletion of 17p13 was found in 11 (16.6%) and deletion 6q21 was present in 5 (7.5%). statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings...
Biological techniques such as Array-Comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH) and affymetrix single nucleotide pleomorphism (SNP) array have been used to detect cytogenetic aberrations. However, on genomic scale, these techniques are labor intensive and time consuming. Comparative genomic microarray analysis (CGMA) has been used to identify cytogenetic ch...
introduction: most of the hematologic malignancies are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. patients and methods: bone marrow sam...
BACKGROUND Diffuse large B-cell lymphoma (DLBCL) accounts for up to 40% of all non-Hodgkin's lymphomas diagnosed in the western hemisphere. Determination of the gene expression profile has confirmed the physiological heterogeneity of the disease and defined three molecular prognostic subgroups - germinal center B-cell-like (GCB), activated B-cell-like (ABC) and primary mediastinal B-cell lympho...
Background. Diffuse large B-cell lymphoma (DLBCL) accounts for up to 40% of all non-Hodgkin’s lymphomas diagnosed in the western hemisphere. Determination of the gene expression profile has confirmed the physiological heterogeneity of the disease and defined three molecular prognostic subgroups – germinal center B-cell-like (GCB), activated B-cell-like (ABC) and primary mediastinal B-cell lymph...
Clonal cytogenetic aberrations of the Philadelphia chromosome (Ph) positive hematopoiesis have been associated with the natural evolution of chronic myeloid leukemia (CML) to advanced disease. Clonal aberrations of Ph negative metaphases have been described after treatment with interferon or imatinib. This study evaluates the effect of dasatinib on Ph positive clones with additional cytogenetic...
the frequency of chromosomal aberrations was studied in the peripheral blood lymphocytes of 65 radiology technologists crt) working at hospitals chronically exposed to x-rays. although film dosimetry did not show the maximal annual permitted dose in any of the examined subjects, cytogenetic analysis detected fairly high levels of chromosomal aberrations in r t compared to unexposed controls. th...
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