a better understanding of the mechanism of chromosomal aberration formation could be obtained by using dna repair inhibitors. immortalized normal human (mrc 5 svi) and ataxia telangiectasia ( at 5 biv a ) fibroblastic cell lines were treated with adenosine arabinoside (ara-a) and cytosine arabinoside (ara-c), both potent inhibitors of dna dsb repair, alone or in combination with x-rays at g2 or...

Figure 1 shows the survival of all patients treated in two consecutive periods at the HSC. Before 1972 patients received a variety of drugs; between 1972 and 1975 daunorubicin and cytosine arabinoside (araC) were used in induction, CNS prophylaxis was given with intrathecal chemotherapy and treatment continued . with 6-mercaptopurine or thioguanine for 2 years. There was no improvement in media...