Survival times of C57BL/6J X DBA/2J Fj mice, inoculated with LI210 or LSI78Y ascites tumor cells, were monitored following treatment with cytosine arabinoside, L-asparaginase, and 6-azauridine, alone and in combination. Each tumor line was sensitive to cytosine arabinoside. L-Asparaginase produced cures (60-day survivors) in 20 to 30% of L5178Y hosts but was totally ineffective against L1210. 6...

INTRODUCTION Modern therapy makes it possible for 60-80% patients with acute myeloid leukemia to achieve complete remission after induction therapy. However, most of them will relapse within six months to a year without additional cytostatic therapy. The questions regarding post-remission therapy remain unanswered. The objective of this study was to compare the survival and relapse rate among t...

application of nuclear magnetic resonance imaging (nmri) as a non-invasive and accurate imaging procedure has been widely used in recent years. meanwhile, the biological effects of magnetic fields of several tesla (t) and high energy radiofrequency (rf) is not fully known yet. because of controversy over this issue, the present research has been carried out in order to verify the effects of mag...

Depression of thymidylate synthetase activity by cytosine arabinoside in CCRF-CEM cells was correlated with a blocking of precursor incorporation into RNA and with cell lysis. With increasing concentrations of cytosine arabinoside in the culture media, a proportional decrease of uridine incorporation into RNA and decrease in thymidylate synthetase activity occurred and was accompanied by lysis ...

A mouse leukemia L1210 cell line was selected for resistance to deoxyguanosine. The deoxyguanosine-resistant cells (dGuo-R) were 126-fold less sensitive to deoxyguanosine than the wild-type cells. The IC50 values for araC and araG were increased, but only 10-12-fold in the dGuo-R cells when compared with the wild-type cells. The dGuo-R cell line showed an increased level of resistance to 2-fluo...

By VILLIAM H. BELL, JACQUELINE J. \\IIANC, PAUL P. CARBONE, GEORGE BIuCIIEJI AND JEROME B. BLOCK T HE BIOLOGICAL ACTIVITY of cytosine arabinosid& (1-/3-D-arabinofuranosylcytosine hydrochloride) has included inhibition of the multiplication of both neoplastic cells in animal systems23 and of DNA viruses.4’ Megaloblastosis and abnormal mitotic figures in marrow aspirates have l)een associated wit...

The combined treatment of cultures of human embryonic lung cells with herpes simplex virus type 2 and cytosine arabinoside produced a significantly increased number of cells containing multiple chromatid and chromosome breaks. The incidence of such cells was found to be approximately two and one half times greater than the additive effects of virus and cytosine arabinoside induced separately an...