Vitamin D3 causes potent suppression of various cancer cells; however, significant supraphysiological concentrations of this compound are required for antineoplastic effects. Current combinatorial therapies with vitamin D3 are restricted to differentiation effects. It remains uncertain if autophagy is involved in vitamin D3 inhibition on leukemia cells. Here we show that besides triggering diff...

[(11)C]-(+)-PHNO is a D3 preferring PET radioligand which has recently opened the possibility of imaging D3 receptors in the human brain in vivo. This imaging tool allows characterisation of the distribution of D3 receptors in vivo and further investigation of their functional role. The specific [(11)C]-(+)-PHNO signal is a mixture of D3 and D2 components with the relative magnitude of each com...

BACKGROUND The three main vitamin D metabolizing enzymes, vitamin D3-25-hydroxylase (25-OHase, 25-hydroxylase), 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-OHase, 1alpha-hydroxylase) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase, 24-hydroxylase), have been described in malignant breast tissue. This in vitro study aimed to obtain more information regarding the regulation of these enzymes...

Let us consider analogous problem for the metric space (X, d) with at least four points. Let A,B,C ∈ X be three fixed points. Then, for the point M ∈ X we suppose that a triangle can be formed from the distances d1 = d(M,A), d2 = d(M,B) and d3 = d(M,C) iff the following conjunction of inequalities is true: d1 + d2 − d3 ≥ 0 and d2 + d3 − d1 ≥ 0 and d3 + d1 − d2 ≥ 0. (1.1) If in conjunction (1.1)...

BACKGROUND Little if any cutaneous production of vitamin D3 occurs at latitudes above and below 35° N and 35° S during the winter months. It was postulated that those residing in tropics synthesize enough vitamin D3 year round. Several studies have documented the effect of latitude, season and time of the day on the cutaneous production of vitamin D3 in an ampoule model. Studies from India have...

The D2-class of dopamine receptors (D2, D3, and D4) is a target for typical and atypical neuroleptic drugs. They have been considered, therefore, as factors that may contribute to the pathophysiology of psychotic disorders. Interestingly, in cortical brain tissues obtained postmortem form patients with chronic schizophrenia D3 mRNA was found to be significantly lower than in the corresponding a...

The present study was undertaken to investigate the toxic effects of higher doses (1,00,000 IU i.e. 2.5 mg/kg body weight (BW)) of vitamin D3, concomitantly with bacterial endotoxins (lipopolysaccharides: LPS) to study the immunomodulatory potential of vitamin D3 in IBL-80 broiler chicks. The chicks were divided into four groups [group I (NSS), group II (LPS), group III (Vit. D3 + NSS), and gro...

Background: Vitamin D deficiencies are highly prevalent globally, but the correlation between serum alkaline phosphatase and vitamin D3 deficiency among Indian children is seldom investigated. To describe the correlation of vitamin D3 levels and serum alkaline phosphatase levels among children admitted with malnutrition to the pediatric wards of a tertiary care center. Methods: This descriptiv...

introduction: multiple sclerosis (ms) is a chronic autoimmune disease with unknown etiology affecting the central nervous system. the prevalence of ms is highest where environmental supplies of vitamin d are lowest. some studies have shown a strong protective effect of vitamin d3 in experimental autoimmune encephalomyelitis (eae) a model of ms. however, it is not known whether vitamin d3 has a ...