Bioinformatics is the science of storing, extracting, organizing, analyzing, and interpreting biological data. Its importance has increased with the technology of DNA sequencing, microarrays, as well as the widespread understanding that genes and proteins act in networks. This in turn renders high performance data analysis algorithms central to various bioinformatics tasks. The research topics ...

InterProScan [E. M. Zdobnov and R. Apweiler (2001) Bioinformatics, 17, 847-848] is a tool that combines different protein signature recognition methods from the InterPro [N. J. Mulder, R. Apweiler, T. K. Attwood, A. Bairoch, A. Bateman, D. Binns, P. Bradley, P. Bork, P. Bucher, L. Cerutti et al. (2005) Nucleic Acids Res., 33, D201-D205] consortium member databases into one resource. At the time...

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objective: prostate cancer is the fifth most common cancer. in 2012, it was the second leading cause of cancer death for men worldwide. the pi3k/akt pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. micrornas (mirnas) that regulate gene expression have a special abilit...

in this paper, we propose a new gene selection algorithm based on shuffled frog leaping algorithm that is called sfla-fs. the proposed algorithm is used for improving cancer classification accuracy. most of the biological datasets such as cancer datasets have a large number of genes and few samples. however, most of these genes are not usable in some tasks for example in cancer classification. ...

Viviana Cobos Jiménez, Edward J. Bradley, Antonius M. Willemsen, Antoine H. C. van Kampen, Frank Baas, and Neeltje A. Kootstra Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands; Department of Genome Analysis, Academ...

The development of biotechnology has accelerated, especially during the past ten years, as a result massive amounts data generated by sequencing genomes and solution crystal structures. Future possibilities are given along with description bioinformatics education in India. In order to serve scientific community, Indian government made concerted effort build India's infrastructure 1980s. necess...

objective(s):brucellosis is a well-known domestic animal infectious disease, which is caused by brucella bacterium. groel antigen increases brucella survival and is one of the major antigens that stimulates the immune system. hence, the objective of the present study was cloning and bioinformatics analysis of groel gene. materials and methods: the full-length open reading frame of this gene was...