Inspired by a real-life case in the Brussels Capital Region, Belgium, this paper provides Memetic Algorithm with Sequential Split procedure (MASS) for solving large variety of waste collection problems multiple depots, restricted vehicle fleet at each depot, (intermediate) processing facilities, capacity restrictions per facility and partial pick-ups. MASS first generates satisfactory initial s...

AIMS The aim was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of octreotide subcutaneous (s.c.) depot, a novel octreotide formulation. METHODS This was a phase I, randomized, open label study. After a single dose of octreotide immediate release (IR) 200 µg, subjects were randomized to one of eight groups to receive three monthly injections of octreotide s.c. depot...

Aiming at the multi-depot heterogeneous vehicle routing problem under time-dependent road network and soft time window, considering fixed cost, window penalty cost transportation an optimization model of is established with objective minimizing distribution cost. According to characteristics problem, a hybrid genetic algorithm variable neighborhood search temporal–spatial distance designed. Cus...

Among numerous NP-hard problems, the Traveling Salesman Problem (TSP) has been one of the most explored, yet unknown one. Even a minor modification changes the problem’s status, calling for a different solution. The Generalized Traveling Salesman Problem (GTSP)expands the TSP to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...

<span>This study proposed a hybrid approach of firefly algorithm (FA) and ant colony optimization (ACO) for solving multi-depot multiple traveling salesman problem, TSP with more than one departure city. The FA is fast converging but easily trapped into the local optimum. ACO has great ability to search solution it converges slowly. To get better result convergence time, we integrate find...

Kegiatan export import merupakan kegiatan yang cukup komplek karena melibatkan banyak peran didalamnya seperti pihak Exportir, Importir, Perusahaan Angkutan Barang (darat, laut, maupun udara), Depot Kontainer, Direktorat Bea dan Cukai, Bank, Perindustrian Perdagangan, Asuransi, serta lainnya. Sebagai salah satu perusahaan operator depot kontainer, PT. Multi Sejahtera Abadi mempunyai utama untuk...

Intramuscular formulations of antipsychotics can be sub-divided into two groups on the basis of their pharmacokinetic features: short-acting preparations and long-acting or depot preparations. Short-acting intramuscular formulations are used to manage acute psychotic episodes. On the other hand, long-acting compounds, also called "depot", are administered as antipsychotic maintenance treatment ...