Immune responses against thyroid carcinomas have long been demonstrated and associations between inflammatory microenvironment and thyroid carcinomas repeatedly reported. This scenario has prompted scientists throughout the world to unveil how the inflammatory microenvironment is established in thyroid tumors and what is its influence on the outcome of patients with thyroid carcinoma. Many stud...

Introduction: Differentiated thyroid carcinoma (DTC) is associated with excellent prognosis and high survival rates. This study was conducted to evaluate the influence of baseline and treatment-related factors on the health related quality of life (QoL) in cured DTC. Methods:This study was an analytic cross-sectional study on radio-iodine (RAI) treated DT...

Thyroid hormone receptors, THRA and THRB, together with the TSH receptor, TSHR, are key regulators of thyroid function. Alterations in the genes of these receptors (THRA, THRB and TSHR) have been related to thyroid diseases, including thyroid cancer. Moreover, there is evidence suggesting that predisposition to differentiated thyroid cancer (DTC) is related to common genetic variants with low p...

OBJECTIVE To define clinical presentation, surgical complications, follow-up characteristics, and survival of 23 children and adolescents with thyroid carcinoma. DESIGN Retrospective analysis of data of 23 children and adolescents with thyroid carcinoma cared for in the Theagenion Cancer Hospital, Thessaloniki. RESULTS At the time of diagnosis cervical lymph node metastases were present in ...

Differentiated thyroid cancer (DTC) originates from thyroid follicular epithelial cells and belongs to a group of slowly progressing tumors with relatively good prognosis. However, optimal results in the treatment of these tumors via coordinated multimodal therapy are achieved mostly by early diagnosis. A serious problem in course of DTC are recurrences and metastasis. Conversion from well diff...

Well-differentiated thyroid cancer (DTC) carries an excellent prognosis. Although long-term survival rates are high, regional lymph node metastases are common. Surgical management of cervical lymph nodes is integral to the comprehensive treatment of DTC, but data from large randomized trials do not exist to define optimal treatment. Therapy is thus guided by observational data, and founded on a...

The vast majority of patients with differentiated thyroid cancer (DTC) are treated successfully with surgery and radioactive iodine ablation, yet the treatment of advanced cases is frustrating and largely ineffective. Systemic treatment with conventional cytotoxic chemotherapy is basically ineffective in most patients with advanced DTC. However, a better understanding of the genetics and biolog...

A49-year-old female presented to the hospital with abdominal pain and emesis. A computed tomography (CT) scan revealed a small-bowel obstruction and a right ovarian mass measuring 4.6 cm. Following oophorectomy, histopathology revealed a mature cystic teratoma with multiple foci of benign thyroid tissue, as well as a 0.9 cm focus of follicular variant papillary thyroid cancer (Figs. 1 and 2) su...

Patient's age at the time of diagnosis is an important prognostic factor for differentiated thyroid cancer (DTC) as reflected in various staging and risk stratification systems. However, discrepancies exist among the different staging systems on an optimal cut-off age for predicting the clinical outcome of patients with DTC. To determine the age at diagnosis most predictive of clinical outcomes...

Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. This malignancy generally has an excellent prognosis with more than 90% long term survival. Consequently, life quality improvement is the first priority especially in the young DTC survivors. In classic management of a new DTC patient, each therapeutic modality can significantly induce morbidities. In the...