Background: The aim of this study was to understand any association between differentiated thyroid carcinoma (DTC) and Ile3434Thr XRCC7 gene polymorphism (GenBank accession number: rs7830743). DTC is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. XRCC7 gene encodes a protein that functions in non-homologous end joining DNA repair pathway. Non-synony...

background: the aim of this study was to understand any association between differentiated thyroid carcinoma (dtc) and ile3434thr xrcc7 gene polymorphism (genbank accession number: rs7830743). dtc is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. xrcc7 gene encodes a protein that functions in non-homologous end joining dna repair pathway. non-synony...

Objective The extent of surgery for differentiated thyroid carcinoma (papillary and follicular) is still controversial, extending from simple lobectomy to extensive total thyroidectomy. The objective of this study was to assess the outcome of different types of thyroidectomy in patients with differentiated thyroid carcinoma (DTC). Methods The extent of primary surgical therapy for 428 patients ...

background: x-ray repair cross-complementing group 1 (xrcc1) gene is a dna repair gene and its non-synonymous single nucleotide polymorphisms (snp) may influence dna repair capacity which has been considered as a modifying risk factor for cancer development. methods: a case-control study was conducted to investigate impact of three frequently studied polymorphisms (arg194trp, arg280his and arg3...

Differentiated thyroid carcinoma (DTC) has a favorable prognosis, but it is important to identify those patients who have a high risk of progressive disease and DTC-related death at the time of diagnosis. Analyzing genetic and epigenetic alterations in thyroid cancer may play a role in tumor diagnosis, prognostic and therapeutic strategies.

Background: Differentiated thyroid carcinoma (DTC) is the most prevalent thyroid neoplasm which includes papillary and follicular cell carcinoma. Exposure to ionizing radiation is a predisposing factor for developing DTC. Non Homologous End Joining (NHEJ) DNA repair pathway is important one among DNA repair pathways which rejoins ends of broken DNA strands. XRCC4 gene is one of the most importa...

OBJECTIVE In the present study we analyzed the pattern of pendrin (PDS) and sodium/iodide symporter (NIS) gene expression in some thyroid carcinoma cell lines and a series of thyroid tumoral tissues. METHODS Total RNA was extracted from all cell lines and from 53 tissues, and gene expression was examined by RT-PCR. Semiquantitative 'multiplex' RT-PCR was used to assess variations in PDS gene ...

INTRODUCTION Differentiated thyroid carcinoma (DTC) is a rare childhood malignancy, as it represents 0.3-0.4% of pediatric malignancies. Papillary carcinoma is the most common type of pediatric DTC and it represents about 90% of all DTC patients. Although rare, DTC arising from dyshormonogenetic goiter is the most serious complication of congenital hypothyroidism. CASE REPORT We presented the...

OBJECTIVES To analyze the clinical and histopathological features of patients with thyroid cancer in the southwest Madrid area and to identify poor prognostic factors in the subgroup with differentiated thyroid carcinoma (DTC) of the follicular epitelium. PATIENTS AND METHODS A retrospective cohort study of patients diagnosed with thyroid cancer at our hospital from 1998 to 2009. Significant ...

introduction:  in order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (dtc), after l-t4 withdrawal (short-term overt hypothyroidism) and during tsh suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. methods: 24 patients with dtc were studied in two phases: 1: at least 4 weeks after l-t4 withdr...