3,3'-Diindolylmethane (DIM), one of the active products derived from Brassica plants, is a promising antitumor agent. The present study indicated that DIM significantly induced apoptosis in U937 human leukemia cells in dose- and time-dependent manners. These events were also noted in other human leukemia cells (Jurkat and HL-60) and primary human leukemia cells (AML) but not in normal bone marr...

AMA Wysokińska M, Kołota A. The level of consumers’ knowledge on the influence ethyl alcohol health – a review literature. Alcoholism and Drug Addiction/Alkoholizm i Narkomania. 2022;35(4):307-324. doi:10.5114/ain.2022.126947. APA Wysokińska, M., & Kołota, (2022). Narkomania, 35(4), 307-324. https://doi.org/10.5114/ain.2022.126947 Chicago Martyna, Aleksandra Kołota. 2022. "The literature". Nark...

The function of insulin receptor substrate-1 (IRS-1), a keymolecule of insulin signaling, is modulated by phosphorylation at multiple serine/ threonineresidues.Phorbolesterstimulationofcells inducesphosphorylation of two inhibitory serine residues in IRS-1, i.e. Ser-307 and Ser-318, suggesting that both sites may be targets of protein kinase C (PKC) isoforms.However, in an in vitro systemusinga...

We define a Cartesian product G ×H for finite simple graphs which satisfies the Künneth formula H(G × H) = ⊕i+j=kH(G) ⊗ H(G) and so pG×H(x) = pG(x)pH(y) for the Poincaré polynomial pG(x) = ∑ k=0 dim(H (G))x and χ(G × H) = χ(G)χ(H) for the Euler characteristic χ(G) = pG(−1). The graph G1 = G × K1 is homotopic to G, has a digraph structure and satisfies the inequality dim(G1) ≥ dim(G) and G1. Hod...

Two populations of human natural killer (NK) cells can be identified in peripheral blood. The majority are CD3(-)CD56(dim) cells while the minority exhibits a CD3(-)CD56(bright) phenotype. In vitro evidence indicates that CD56(bright) cells are precursors of CD56(dim) cells, but in vivo evidence is lacking. Here, we studied NK cells from a patient that suffered from a melanoma and opportunistic...

http://www.sciencemag.org/cgi/content/full/307/5708/423 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/307/5708/423/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...

http://www.sciencemag.org/cgi/content/full/307/5713/1226 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/307/5713/1226/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. Groups of four subjects were enro...

3,3'-Diindolylmethane (DIM) is a stable condensation product of indole-3-carbanol, a potential breast cancer chemoprevention agent. Human breast cancer cell lines were studied to better understand its mechanisms. In vitro experiments were done in MCF-7, T47D, BT-20 and BT-474 cells using MTT, ELISA, immunoblotting assays, reverse transcription-PCR, protein half-life, confocal microscopy, cell f...