Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share ...

The aetiology of chronic thromboembolic pulmonary hypertension (CTEPH) is largely unknown and may be heterogeneous, because there are several ethnic differences in the clinical characteristics of CTEPH. Female predominance and a higher ratio of chronic to acute pulmonary thromboembolism have been reported in Japan as compared with the USA. Because such ethnic differences may be controlled by ge...

OBJECTIVE To assess the effect of a prospective screening strategy for the early diagnosis of celiac disease (CD) in children with Down syndrome (DS). STUDY DESIGN Blood samples were taken from 155 children with DS. Buccal swabs were also taken from 9 of these children for determination of human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positivity. Independently, immunoglobulin A anti-endomysium...

BACKGROUND Estimates of the diagnostic performance of serologic testing and HLA-DQ typing for detecting celiac disease have mainly come from case-control studies. OBJECTIVE To define the performance of serologic testing and HLA-DQ typing prospectively. DESIGN Prospective cohort study. SETTING University hospital. PATIENTS Patients referred for small-bowel biopsy for the diagnosis of cel...

BACKGROUND: During the last five years the proportion of HLA matching is relevant for cadaver kidney allocation of living unrelated kidney transplants has increased and and in living donor selection if choice for donors with DNA tissue-typing methods have become popular in India. better match is available. In India however, due to paucity This study was carried out to compare the results of tis...

OBJECTIVE There have been reports of a relationship between human histocompatibility antigen types and increased incidence of dental caries. The association between specific patterns of HLA genetic inheritance is not clear and not well studied. The aim of the study was to investigate the relationship between MHC alleles and DMFT index in 65 teenagers. MATERIALS AND METHODS Sixty-five teenager...

To determine whether genetic factors could be involved in the pathogenesis of rheumatic heart disease, we performed HLA-A and HLA-B typing in 120 black patients with severe chronic rheumatic heart disease requiring cardiac surgery, and HLA-DR and HLA-DQ typing in 103 and 97 of these patients, respectively. The HLA typing was done by a standard microlymphocytotoxicity method. Patients were 12 to...