Cross-docking is a an important logistics strategy in which freight is unloaded from inbound vehicles and directly loaded into outbound vehicles, with little or no storage in between. This study considers a crossdocking system which combines the vehicle routing problem with crossdocking (VRPCD) for both inbound and outbound operations and truck sequencing problem at docks. The objective is to m...

Zinc-dependent histone deacetylase 8 removes the epsilon-acetyl groups present in the N-terminal lysine residues of histone proteins, thereby restricting various transcription factors from being expressed. Inhibition of this enzyme has been reported to be a novel strategy in cancer treatment. To identify novel and diverse leads for use in potent histone deacetylase 8 inhibitor design, a pharmac...

The development of wisdom agriculture with agricultural found Chinese demand. The development of wisdom agriculture has the characteristics of integrity, functional and systematic. The article analyzes the main issues and influencing factors according to the current wisdom agriculture in China, such as the gap between domestic and abroad, wisdom, the wisdom agriculture rural development e-gover...

Cross-docking is a warehousing strategy in logistics used by process industries making products with high proportions of distribution costs. It is described as the process of moving goods from suppliers to customers through a cross-dock terminal without a long-term storage in this facility. The vehicle routing problem with cross-docking (VRPCD) consists of fulfilling a set of transportation req...

Protein–ligand docking is the major workhorse in computeraided structure-based lead finding and optimization. Predicted protein–ligand complex configurations are used for studying protein–ligand interactions, estimating binding affinities, and as a final filter step in virtual screening. Early methods on protein–ligand docking treated either both proteins and ligands as rigid molecules or allow...

Microelectromechanical system (MEMS) technology promises to improve performance of future spacecraft components while reducing mass, cost, and manufacture time. Arrays of microcilia actuators offer a lightweight alternative to conventional docking systems for miniature satellites. Instead of mechanical guiding structures, such a system uses a surface tiled with MEMS actuators to guide the satel...

A common strategy for virtual screening considers a systematic docking of a large library of organic compounds into the target sites in protein receptors with promising leads selected based on favorable intermolecular interactions. Despite a continuous progress in the modeling of protein-ligand interactions for pharmaceutical design, important challenges still remain, thus the development of no...

monoamine oxidase (ec, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. abnormal action of the monoamine oxidase b has been associated with neurological dysfunctions including parkinson´s disorder. monoamine oxidase b inhibitors divulged that these agents were effective in the therapeutic management of parkinson's disease. understanding the interaction of...