Metal dental restoration materials cause dose enhancement upstream and dose disturbance downstream of the high-density inhomogeneous regions in which these materials are used. In this study, we evaluated the impact of a dental metallic crown (DMC) on intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for head and neck cancer. Additionally, the possibility of spa...

Fludarabine (9-beta-D-arabinofuranosyl-2-fluoroadenine-5'-monophosphate), an adenine nucleoside analogue, has previously been shown to inhibit the repair of radiation-induced chromosome damage. Thus fludarabine may have therapeutic utility in combination with photon irradiation. The purpose of this study was to determine whether fludarabine could enhance radiation-induced murine tumor regrowth ...

Values for thermal enhancement and therapeutic gain are useful for deciding future directions of hyperthermia combined with other cancer therapy modalities. Evidence of thermal enhancement of effects on normal tissues is important as it indicates the need for dose modification. Specific values cannot be used generally to determine the degree of dose modification for clinical applications. A ran...

Objective: Most   neonates admitted to neonatal wards do not tolerate sufficient milk.  Recently the effect of erythromycin on increasing feeding tolerance in neonates has been studied. In this study the effectiveness of oral, high dose Erythromycin a prokinetic agent was used to enhance feeding tolerance in these neonates.  Methods: This prospective randomized controlled clinical trial was con...

Introduction: Currently, the potential application of gold nanoparticles (AuNPs) to increase the efficiency of radiation therapy have been investigated. However, the loss of an appropriate method to estimate the dose distribution in nanoparticle laden tissue limits the applicability of nanoparticles in radiotherapy clinics. Polymer gel dosimetry provides an accurate and precise...

Introduction: SOX9 is a transcriptional activator which is necessary for chondrogenesis. SOX6 are closely related to DNA-binding proteins that critically enhance its function. Therefore, to carry out the growth plate chondrocyte differentiation program, SOX9 and SOX6 collaborate genomewide. Chondrocyte differentiation is also known to be promoted by glucocorticoids through unknown molecular mec...

background: radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like phantom developed to date. objective: the aim of this study is an investigating of percentage depth dose enhancement within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. methods: in this work...

PURPOSE To determine the dose of contrast medium and the imaging strategy sufficient to detect diffusion of low-molecular-weight gadolinium-containing contrast media into normal intervertebral disks. METHODS In 11 rabbits, sequential MR images were obtained of the spine for 120 minutes after intravenous injection of gadopentetate dimeglumine in doses of 0.1 to 2.8 mmol/kg. Images were inspect...

One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization perfor...