Human hepatocytes, with complete hepatic metabolizing enzymes, transporters and cofactors, represent the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and hepatotoxicity. Successful cryopreservation of human hepatocytes enables this experimental system to be used routinely. The use of human hepatocytes to evaluate two major adverse drug properties: drug-drug ...

the marked shift in the patterns of drug use in iran, from opium smoking to injecting drug use, has led to serious health-related outcomes. this study was designed to explore characteristics of people who inject drugs (pwid) in tehran, iran. nine hundred and four pwid were recruited from treatment and harm reduction facilities, as well as drug user hangouts in public areas in tehran. participan...

Aim: Drug intoxications and drug uses are public health problems an important reason for patient admission to emergency departments intensive care units (ICU).This study aims evaluate the demographic clinical data of acute use.
 Methods: Patients followed up in ICU use between January 2014 2020 were evaluated retrospectively.
 Results: A total 194 patients included study, including 16...

this is a report of a case study on 234 patients with impetigo who referred to razi dermatology hospital from april to november, 1989. treatment was started immediately after obtaining direct smear and performing culture and antibiotic sensitivity test. the most common organism responsible for impetigo was the coagulase-positive staphylococcus (71%). in 13.7% of the cases, the coagulase-negativ...