The mammalian growth plate is a dynamic structure rich in extracellular matrix (ECM). Interactions of growth plate chondrocytes with ECM proteins regulate cell behavior. In this study, we compared chondrocyte adhesion and spreading dynamics on fibronectin (FN) and bone sialoprotein (BSP). Chondrocyte adhesion and spreading were also compared with fibroblasts to analyze potential cell-type-speci...

This study analyzes signaling events initiated through binding of the leukocyte integrin LFA-1 to ICAM-1, which leads to T cell attachment, polarization and random migration. These events are critically dependent on dynamic changes in the acto-myosin cytoskeleton under the regulation of myosin light chain kinase and ROCK (Rho kinase). A key finding is that the activity of these two kinases is s...

Rock pools are dynamic and intermittently isolated habitats in the rocky intertidal. They can be used as model systems to provide a more general insight into the ecology of patchy habitats, which are less amenable to experimentation, such as islands and wildlife reserves. In the present study, a range of pools of differing sizes was selected at 2 vertical levels on the shore to assess the impor...

Researchers at the National Institute for Occupational Safety and Health (NIOSH), Spokane Mining Research Division (SMRD) have developed a modeling framework, using commercially available software, for investigating the fracture and ejection of rock into underground mine openings caused by seismic loading and the restraint of this failed rock by the ground support system. The modeling framework...

Hyperlipidemia is a major cardiovascular risk factor associated with progressive cerebrovascular dysfunction and diminished collateral perfusion in stroke. Rho-associated kinase (ROCK) may be an important mediator of hyperlipidemic vascular dysfunction. We tested the efficacy of acute or chronic ROCK inhibition on the size of dynamic perfusion defect using laser speckle flowmetry in hyperlipide...

Strength reduction method and ADINA software are adopted to study the stability of submarine tunnel structures subjected to seepage and earthquake under different seawater depths and overlying rock strata thicknesses. First, the excess pore water pressure in the rock mass is eliminated through consolidation calculation. Second, dynamic time-history analysis is performed by inputting the seismic...

Today, numerical simulation can be used as a suitable tool to measure large quantities that are very expensive and, in some cases, impossible to measure. One of the important issues in predicting rock mass boreability in excavation with full face tunnel boring machines is estimating the discchr('39')s forces for rock cutting. For this purpose, the linear cutting test is  employed. However, limi...

explosion has always been regarded as one of the most complicated engineering problems. as a result, many engineers have preferred rather simplified empirical approaches in comparison to extremely complex deterministic analyses. in this paper, however, a numerical simulation based on the combined finite/discrete element methodology is presented for analyzing the dynamic behavior of fracturing r...