Abstract Immortality is a fundamental hallmark of human cancer cells and therapeutic reversal great interest. Telomerase Reverse Transcriptase promoter (TERTp) mutations reactivate TERT expression, the rate limiting step in telomerase activity cellular immortality. TERTp are most common non-coding mutation across all types, including glioblastoma (GBM), oligodendroglioma, medulloblastoma, high-...

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Urethral Reconstruction (including Stricture, Diverticulum) I (MP03)1 Sep 2021MP03-14 DURABLE TREATMENT OF REFRACTORY VESICOURETHRAL ANASTOMOTIC STENOSIS VIA ROBOTIC-ASSISTED RECONSTRUCTION: A TRAUMA AND UROLOGIC RECONSTRUCTIVE NETWORK SURGEONS STUDY Nabeel Shakir, Nejd Alsikafi, Julia Buesser, Gregory Amend, Benjamin Breyer, Jil...

Abstract Adoptive regulatory T-cell (Treg) therapy is an emerging therapeutic paradigm for promoting immune tolerance in transplant and autoimmune disease settings. Prior investigations demonstrate that murine Tregs can undergo epigenetic reprogramming within chronically inflamed tissue environments, resulting acquisition of proinflammatory functions the capacity to exacerbate damage. Despite r...

underground economy affects important indexes such as formal gdp, unemployment, consumption, production and etc. therefore it is necessary to identify elements and factors which affect underground economy to restrict it. surveys and studies indicate the size of iran’s underground economy is high and taxes, quantity and quality of regulations and performance of formal economy are the important f...