Recent progress in genome-scale sequencing and comparative mapping raises new challenges in studies of genome rearrangements. Although the pairwise genome rearrangement problem is well-studied, algorithms for reconstructing rearrangement scenarios for multiple species are in great need. The previous approaches to multiple genome rearrangement problem were largely based on the breakpoint distanc...

From first-principles calculations, we investigate the structural and electronic properties of kagome metals ${A\mathrm{V}}_{3}{\mathrm{Sb}}_{5}$ $(A=\mathrm{Cs}, \mathrm{K}, \mathrm{Rb})$ under isotropic anisotropic pressure. Charge-ordering patterns are found to be unanimously suppressed, while there is a significant rearrangement $p$-type $m$-type Van Hove point energies with respect Fermi l...

The realization of efficient water electrolysis is still blocked by the requirement for a high and stable driving potential above thermodynamic requirements. An Ni-based electrocatalyst, promising alternative noble-metal-free electrocatalysts but tuning its surface electronic structure exposing more active sites are critical challenges to improving intrinsic catalytic activity. Here, we tackle ...

The Claisen rearrangement and its applications to organic synthesis have been studied for a long time.l In recent years, this rearrangement has been applied in stereocontrolled natural product synthesis2 and asymmetric i n d ~ c t i o n . ~ The term "Claisen rearrangement", which originally denoted the rearrangement of allyl aryl ethers to 0or p-allylphenols, has now been extended to analogous ...

A functional B cell antigen receptor is thought to regulate antibody gene rearrangement either by stopping further rearrangement (exclusion) or by promoting additional rearrangement (editing). We have developed a new model to study the regulation of antibody gene rearrangement. In this model, we used gene targeting to replace the J kappa region with a functional V kappa-J kappa light chain gene...

A likely mechanism of chromosomal rearrangement formation involves joining the ends from two different chromosomal double-strand breaks (DSBs). These events could potentially be mediated by either of two end-joining (EJ) repair pathways [canonical nonhomologous end joining (C-NHEJ) or alternative end joining (ALT-EJ)], which cause distinct rearrangement junction patterns. The relative role of t...

Here we show that suppression of VH-DJH rearrangement in mice bearing a mu heavy (H) chain transgene (mu-tg mice) is associated with an extended period of DH-JH rearrangement, the first step of Immunoglobulin H chain gene rearrangement. Whereas DH-JH rearrangement is normally initiated and completed at the pro-B cell stage, in mu-tg mice it continues beyond this stage and occurs most frequently...

In this paper, a novel method for loss reduction and efficiency optimization of the high frequency flyback transformers is proposed based on rearrangement of the windings. According to detailed analysis of the high frequency flyback transformer using FEM technique, a novel and simple approach for its design improvement and loss reduction is introduced. It is shown that leakage flux scattering i...

substituted naphthofurans and naphthopyrans were constructed at high temperature from allyl or propargyl naphthyl ethers via claisen rearrangement in moderate to good yields. also, substituted (trimethylsilyl)-naphthofurans were synthesized from the corresponding naphtofurans.