The purpose of the study Our study was centred on the comparative research of enzymatic and non-enzymatic oxidative status mediators in the crevicular fluid on chronic and aggressive periodontitis patients, compared to periodontal healthy subjects. Materials and methods The study was conducted on 42 patients. They were divided in 3 study groups: chronic periodontitis subjects, aggressive period...

BACKGROUND AND OBJECTIVE Daidzein is an isoflavone abundant in soybeans, kudzu root and red clover, which have been widely studied for its therapeutic potential. The present study was designed to evaluate the effects of daidzein on alveolar bone loss and internal microstructures of bone in a rat model of experimental periodontitis by assessing morphological data obtained from micro-computed tom...

BACKGROUND & OBJECTIVE The role of lathyrogens on bone metabolism is unclear, therefore we undertook this study to observe periodontal and systemic alterations in experimental lathyrism in rat and compare these changes to that observed in the locally induced periodontitis group. METHODS A total of 45 male Wistar rats were equally divided in the lathyritic group (group 1), ligature-induced per...

Periodontitis and osteoporosis are two diseases found in both male and female population worldwide. The main characteristic of the two diseases is their increased intensity with age. Periodontitis is associated with resorption of the alveolar bone. Osteoporosis, as the highest degree of osteopenia, is characterized by bone loss leading to structural bone transformation. The association between ...

Objective Periodontitis is one of the main diseases in the oral cavity that causes tooth loss. The host immune response and inflammatory factors have important role in periodontal tissue. The current study was done with the objective to determine the effect of scaling and root planning on the salivary concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-alpha (IL-1α). Metho...

BACKGROUND AND OBJECTIVE Growing experimental evidence implicates chronic inflammation/infection due to periodontal diseases as a risk factor for death. The objective was to evaluate the role of periodontitis in premature death in a prospective study. METHODS The causes of death in 3273 randomly-selected subjects, aged 30-40 years, from 1985 to 2001 were registered. At baseline, 1676 individu...

OBJECTIVES To analyze the anti-inflammatory effects of Lactobacillus brevis extracts on periodontitis patients and to investigate the involved mechanisms in vitro on activated macrophages. METHODS Eight healthy subjects and 21 patients with chronic periodontitis were enrolled to analyze the effect of L. brevis-containing lozenges on periodontitis-associated symptoms and signs. Before and afte...

This study investigated some immunological features by experimental periodontitis (EP) and rheumatoid arthritis (RA) disease interact in destructive processes in arthritic rats. Rats were assigned to the following groups: EP +RA; RA; EP; and Negative Control. RA was induced by immunizations with type-II collagen and a local immunization with Complete Freund's adjuvant in the paw. Periodontitis ...

Periodontal disease with its systemic implications is highly prevalent among the population, and this correlation could have an impact on the quality lives of many humans. The purpose of this study was to assess the clinical and histopathological changes of the periodontium correlated with the systemic inflammatory response in periodontal disease. An experimental study was performed on male Wis...