The long-termfollow-up over a period of2 to 5years of thefirst 7 survivors of complete correction with homograft reconstruction in pulmonary outflow atresia and extreme Fallot has been studied. Symptomatically, the patients have remained excellent with return to normal of the chest x-rays and electrocardiograms. Investigation has shown continued good function of the homograft aortic valve in th...

T ability of h,',rologo"" antilymphocyte serum (ALS) or its globulin derivative (ALG) to mitigate or even prevent homograft rejection is well known. In early investigations with skin homotransplantation in inbred rodents, it was shown that ALS given even several days after arrival of the homograft resulted in definite prolongation of transplant survival,4,7 This communication concerns an extens...

.he recent medical literature is replete with reports of the use of antilymphocytic serum (ALS) as an immunosuppressive agent in the prevention of homograft reactions.' 2 This agent has been successfully used in preventing corneal homograft and xenograft reactions with intralamellarly placed donor tissue.' The following study was instituted to test the effectiveness of ALS in preventing immune ...

OBJECTIVES False aneurysm of the right ventricular outflow tract (RVOT) is one of complications after surgery of congenital heart disease. It is controversial about materials for reconstruction of RVOT in this setting, when associated with pulmonary hypertension or bacterial infection. Pulmonary homograft seems to be the first choice, but its availability is extremely limited in Japan. METHOD...

Gross and microscopic observations of skin homograft rejection carried out in cortisone-conditioned and non-conditioned rabbits seem to indicate that humoral antibodies play an important role in the phenomenon. Thus, local administration of isoimmune serum to animals bearing skin homografts resulted in a significantly earlier rejection of that particular test graft without modifying the course ...

Thirty-seven patients with extensive acetabular defects due to loose implants had revisions with uncemented components, the acetabulum being augmented with homograft bone. In six of these, a histological study of graft incorporation was made. At a mean follow-up of 1.5 years 34 patients were free of pain and 35 could walk for 30 minutes or longer. No graft had obviously sequestrated. Two compon...

Skin transplanted as a homograft from one animal to a genetically dissimilar animal of the same species is rejected after nine to twelve days, probably because of actively acquired immune reactions (Medawar 1944, 1945; Billingham, Brent and Medawar 1954; Billingham, Brent, Medawar and Sparrow 1954). The acquired resistance is termed either transplantation immunity (Billingham, Brent and Medawar...

Tissue transplantation is a life-enhancing therapeutic modality for damaged or non-functioning tissues. In most cases, there is no alternative other than human tissue as replacement, and taking into account the ever-increasing demand for tissue grafts, it makes sense to set up an establishment in charge of human tissue procurement to meet local needs. A quality assurance system, clearly defined...